FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000673564> ?p ?o ?g. }

• W2000673564 endingPage "286" @default.
• W2000673564 startingPage "283" @default.
• W2000673564 abstract "Summary Neoplastic diseases are often associated with thromboembolic events,however the precise mechanism underlying this observation is a matter of ongoing investigation. It is known that matrixmetalloproteinase- 1 (MMP-1) canonically activates the thrombin receptor (PAR-1) and we recently reported that highly metastatic tumor cells of melanoma and colon cancer are secreting matrixmetalloproteinase-1. This tumor-derived MMP1 was shown to be a major activator of endothelial PAR-1, thus leading to endothelial cell activation. As tumor-induced thrombosis is a characteristic of metastazing tumors, we investigated whether tumor-derived supernatant (TUSN) from melanoma and colon cancer may induce adhesion of circulating platelets,an initial step in thrombus formation.A time-course study revealed that TU-SN induces a rapid secretion of von Willebrand factor (VWF) within minutes. Using a novel microfluidic device we analyzed platelet-endothelial interactions in a closed circuit. Immunofluorescence imaging showed that TU-SN rapidly induces platelet- string formation via secreted VWF. We demonstrated that tumor-derived supernatant is a potent agonist inducing platelet adhesion under flow conditions." @default.
• W2000673564 created "2016-06-24" @default.
• W2000673564 creator A5000971864 @default.
• W2000673564 creator A5002927226 @default.
• W2000673564 creator A5004992841 @default.
• W2000673564 creator A5034644244 @default.
• W2000673564 creator A5047684686 @default.
• W2000673564 creator A5072806793 @default.
• W2000673564 creator A5086051455 @default.
• W2000673564 creator A5089460003 @default.
• W2000673564 date "2007-01-01" @default.
• W2000673564 modified "2023-09-26" @default.
• W2000673564 title "Microfluidic reveals generation of platelet-strings on tumoractivated endothelium" @default.
• W2000673564 cites W145459059 @default.
• W2000673564 cites W1868085919 @default.
• W2000673564 cites W1984887148 @default.
• W2000673564 cites W1997981454 @default.
• W2000673564 cites W1998816346 @default.
• W2000673564 cites W1999364304 @default.
• W2000673564 cites W2013821653 @default.
• W2000673564 cites W2042082129 @default.
• W2000673564 cites W2044505929 @default.
• W2000673564 cites W2058458259 @default.
• W2000673564 cites W2086458592 @default.
• W2000673564 cites W2171003020 @default.
• W2000673564 doi "https://doi.org/10.1160/th07-03-0163" @default.
• W2000673564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17721608" @default.
• W2000673564 hasPublicationYear "2007" @default.
• W2000673564 type Work @default.
• W2000673564 sameAs 2000673564 @default.
• W2000673564 citedByCount "41" @default.
• W2000673564 countsByYear W20006735642012 @default.
• W2000673564 countsByYear W20006735642013 @default.
• W2000673564 countsByYear W20006735642014 @default.
• W2000673564 countsByYear W20006735642016 @default.
• W2000673564 countsByYear W20006735642017 @default.
• W2000673564 countsByYear W20006735642018 @default.
• W2000673564 countsByYear W20006735642019 @default.
• W2000673564 countsByYear W20006735642020 @default.
• W2000673564 countsByYear W20006735642022 @default.
• W2000673564 crossrefType "journal-article" @default.
• W2000673564 hasAuthorship W2000673564A5000971864 @default.
• W2000673564 hasAuthorship W2000673564A5002927226 @default.
• W2000673564 hasAuthorship W2000673564A5004992841 @default.
• W2000673564 hasAuthorship W2000673564A5034644244 @default.
• W2000673564 hasAuthorship W2000673564A5047684686 @default.
• W2000673564 hasAuthorship W2000673564A5072806793 @default.
• W2000673564 hasAuthorship W2000673564A5086051455 @default.
• W2000673564 hasAuthorship W2000673564A5089460003 @default.
• W2000673564 hasConcept C123012128 @default.
• W2000673564 hasConcept C126322002 @default.
• W2000673564 hasConcept C142724271 @default.
• W2000673564 hasConcept C185592680 @default.
• W2000673564 hasConcept C202751555 @default.
• W2000673564 hasConcept C203014093 @default.
• W2000673564 hasConcept C2776992346 @default.
• W2000673564 hasConcept C2779394231 @default.
• W2000673564 hasConcept C2779679481 @default.
• W2000673564 hasConcept C2781362458 @default.
• W2000673564 hasConcept C3018697912 @default.
• W2000673564 hasConcept C502942594 @default.
• W2000673564 hasConcept C55493867 @default.
• W2000673564 hasConcept C71924100 @default.
• W2000673564 hasConcept C86803240 @default.
• W2000673564 hasConcept C89560881 @default.
• W2000673564 hasConcept C95444343 @default.
• W2000673564 hasConceptScore W2000673564C123012128 @default.
• W2000673564 hasConceptScore W2000673564C126322002 @default.
• W2000673564 hasConceptScore W2000673564C142724271 @default.
• W2000673564 hasConceptScore W2000673564C185592680 @default.
• W2000673564 hasConceptScore W2000673564C202751555 @default.
• W2000673564 hasConceptScore W2000673564C203014093 @default.
• W2000673564 hasConceptScore W2000673564C2776992346 @default.
• W2000673564 hasConceptScore W2000673564C2779394231 @default.
• W2000673564 hasConceptScore W2000673564C2779679481 @default.
• W2000673564 hasConceptScore W2000673564C2781362458 @default.
• W2000673564 hasConceptScore W2000673564C3018697912 @default.
• W2000673564 hasConceptScore W2000673564C502942594 @default.
• W2000673564 hasConceptScore W2000673564C55493867 @default.
• W2000673564 hasConceptScore W2000673564C71924100 @default.
• W2000673564 hasConceptScore W2000673564C86803240 @default.
• W2000673564 hasConceptScore W2000673564C89560881 @default.
• W2000673564 hasConceptScore W2000673564C95444343 @default.
• W2000673564 hasIssue "08" @default.
• W2000673564 hasLocation W20006735641 @default.
• W2000673564 hasLocation W20006735642 @default.
• W2000673564 hasOpenAccess W2000673564 @default.
• W2000673564 hasPrimaryLocation W20006735641 @default.
• W2000673564 hasRelatedWork W152465027 @default.
• W2000673564 hasRelatedWork W1969171402 @default.
• W2000673564 hasRelatedWork W1972338693 @default.
• W2000673564 hasRelatedWork W2156473494 @default.
• W2000673564 hasRelatedWork W2171240439 @default.
• W2000673564 hasRelatedWork W2401471732 @default.
• W2000673564 hasRelatedWork W2592057741 @default.
• W2000673564 hasRelatedWork W4226050695 @default.
• W2000673564 hasRelatedWork W4229045107 @default.
• W2000673564 hasRelatedWork W4248680398 @default.

• next