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- W2000674290 abstract "Abstract The C3 amplification convertase of human complement, C3b, Bb, is assembled on biological surfaces by the interaction of the alternative pathway proteins B, D and P with cell-bound C3b. Convertase formation is modulated by the action of the regulatory proteins H and I. On activating surfaces of the alternative pathway, C3b, Bb is relatively resistant to regulation by H. In contrast, non-activating surfaces exhibit surface characteristics such as high content in membrane-associated sialic acid or heparin-related material which increase the interaction of H with cell-bound C3b. Thus, finely tuned molecular interactions allow the alternative pathway to function as a major recognition and effector system for natural defence." @default.
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- W2000674290 date "1982-03-01" @default.
- W2000674290 modified "2023-09-27" @default.
- W2000674290 title "Activation de la voie alterne du complément par les surfaces biologiques" @default.
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- W2000674290 doi "https://doi.org/10.1016/0769-2625(82)90031-9" @default.
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