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- W2000674381 abstract "The first microRNA, let-7, and its family were discovered in Caenorhabditis elegans and are functionally conserved from worms to humans in the regulation of embryonic development and stemness. The let-7 family has been shown to have an essential role in stem cell differentiation and tumor-suppressive activity. Deregulating expression of let-7 is commonly reported in many human cancers. Emerging evidence has accumulated and suggests that reestablishment of let-7 in tumor cells is a valuable therapeutic strategy. However, findings reach beyond tumor therapeutics and may impinge on stemness and differentiation of stem cells. In this review, we discuss the role of let-7 in development and differentiation of normal adult stem/progenitor cells and offer a viewpoint of the association between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the application of let-7 are highlighted." @default.
- W2000674381 created "2016-06-24" @default.
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- W2000674381 date "2014-05-01" @default.
- W2000674381 modified "2023-10-03" @default.
- W2000674381 title "Therapeutic Potential of MicroRNA Let-7: Tumor Suppression or Impeding Normal Stemness" @default.
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