Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000674677> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2000674677 endingPage "1573" @default.
- W2000674677 startingPage "1571" @default.
- W2000674677 abstract "End-stage cirrhosis due to hepatitis C virus (HCV) is one of the most common indications for orthotopic liver transplantation (OLT). Recurrence is universal and more aggressive than before OLT. The aim of this study was to evaluate the efficacy and tolerability of antiviral therapy in recurrent HCV after OLT. Therapy was started even with mild fibrosis (F < 2) and extended until 72 weeks, if it was possible.Between November 2001 and December 2010, 279 OLTs were performed in 262 patients in our hospital; 81 (31%) for HCV-related cirrhosis. Nineteen patients were excluded because they died in the first 6 months. We treated 28 of 62 HVC patients.Twenty-eight patients met the indication for antiviral therapy: 21 male (75%) and 7 female (25%), with a mean age of 56 years (range, 40 to 68 years). All the patients had histologically proven recurrence liver disease: F1, 19 patients (68%); F2, 4 patients (14%), and F3, 45 patients (18%). The mean time to recurrence was 23 months, with a range of 3 to 90 months. Adverse effects (leukopenia in 82% and anemia in 79%) were treated with granulocyte colony-stimulating factor (GCSF) and erythropoietin (EPO), and dose reduction. Four patients (14%) were withdrawn from the treatment because of adverse effects. Nineteen patients achieved early virologic response (68%), and the sustained virologic response was 54% (15 of 28 patients). Five patients died (18%).Improving sustained virologic response in HCV liver transplant patients is a key goal. Antiviral therapy is safe and effective treating HCV recurrence after OLT. Starting this therapy in an early stage of hepatitis C recurrence, extending antiviral therapy (72 weeks), and avoiding dose reduction of antiviral drugs could help to achieve higher rates of sustained virological response." @default.
- W2000674677 created "2016-06-24" @default.
- W2000674677 creator A5002158072 @default.
- W2000674677 creator A5005444756 @default.
- W2000674677 creator A5008093274 @default.
- W2000674677 creator A5009496271 @default.
- W2000674677 creator A5059775307 @default.
- W2000674677 creator A5060024665 @default.
- W2000674677 creator A5061613548 @default.
- W2000674677 creator A5078908927 @default.
- W2000674677 date "2012-07-01" @default.
- W2000674677 modified "2023-09-26" @default.
- W2000674677 title "Early and Extended Therapy for Recurrent Hepatitis C after Liver Transplantation" @default.
- W2000674677 cites W1981900811 @default.
- W2000674677 cites W1985395902 @default.
- W2000674677 cites W2018555559 @default.
- W2000674677 cites W2022655980 @default.
- W2000674677 cites W2022760989 @default.
- W2000674677 doi "https://doi.org/10.1016/j.transproceed.2012.05.027" @default.
- W2000674677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22841217" @default.
- W2000674677 hasPublicationYear "2012" @default.
- W2000674677 type Work @default.
- W2000674677 sameAs 2000674677 @default.
- W2000674677 citedByCount "3" @default.
- W2000674677 countsByYear W20006746772013 @default.
- W2000674677 countsByYear W20006746772019 @default.
- W2000674677 crossrefType "journal-article" @default.
- W2000674677 hasAuthorship W2000674677A5002158072 @default.
- W2000674677 hasAuthorship W2000674677A5005444756 @default.
- W2000674677 hasAuthorship W2000674677A5008093274 @default.
- W2000674677 hasAuthorship W2000674677A5009496271 @default.
- W2000674677 hasAuthorship W2000674677A5059775307 @default.
- W2000674677 hasAuthorship W2000674677A5060024665 @default.
- W2000674677 hasAuthorship W2000674677A5061613548 @default.
- W2000674677 hasAuthorship W2000674677A5078908927 @default.
- W2000674677 hasConcept C126322002 @default.
- W2000674677 hasConcept C141071460 @default.
- W2000674677 hasConcept C197934379 @default.
- W2000674677 hasConcept C203014093 @default.
- W2000674677 hasConcept C2522874641 @default.
- W2000674677 hasConcept C2776408679 @default.
- W2000674677 hasConcept C2776455275 @default.
- W2000674677 hasConcept C2776694085 @default.
- W2000674677 hasConcept C2777075537 @default.
- W2000674677 hasConcept C2777214474 @default.
- W2000674677 hasConcept C2778375690 @default.
- W2000674677 hasConcept C2779609443 @default.
- W2000674677 hasConcept C2780873365 @default.
- W2000674677 hasConcept C2911091166 @default.
- W2000674677 hasConcept C71924100 @default.
- W2000674677 hasConcept C90924648 @default.
- W2000674677 hasConceptScore W2000674677C126322002 @default.
- W2000674677 hasConceptScore W2000674677C141071460 @default.
- W2000674677 hasConceptScore W2000674677C197934379 @default.
- W2000674677 hasConceptScore W2000674677C203014093 @default.
- W2000674677 hasConceptScore W2000674677C2522874641 @default.
- W2000674677 hasConceptScore W2000674677C2776408679 @default.
- W2000674677 hasConceptScore W2000674677C2776455275 @default.
- W2000674677 hasConceptScore W2000674677C2776694085 @default.
- W2000674677 hasConceptScore W2000674677C2777075537 @default.
- W2000674677 hasConceptScore W2000674677C2777214474 @default.
- W2000674677 hasConceptScore W2000674677C2778375690 @default.
- W2000674677 hasConceptScore W2000674677C2779609443 @default.
- W2000674677 hasConceptScore W2000674677C2780873365 @default.
- W2000674677 hasConceptScore W2000674677C2911091166 @default.
- W2000674677 hasConceptScore W2000674677C71924100 @default.
- W2000674677 hasConceptScore W2000674677C90924648 @default.
- W2000674677 hasIssue "6" @default.
- W2000674677 hasLocation W20006746771 @default.
- W2000674677 hasLocation W20006746772 @default.
- W2000674677 hasOpenAccess W2000674677 @default.
- W2000674677 hasPrimaryLocation W20006746771 @default.
- W2000674677 hasRelatedWork W1963598722 @default.
- W2000674677 hasRelatedWork W1980436799 @default.
- W2000674677 hasRelatedWork W2049581320 @default.
- W2000674677 hasRelatedWork W2053096801 @default.
- W2000674677 hasRelatedWork W2068802639 @default.
- W2000674677 hasRelatedWork W2166316093 @default.
- W2000674677 hasRelatedWork W2380081200 @default.
- W2000674677 hasRelatedWork W2399503113 @default.
- W2000674677 hasRelatedWork W2552831942 @default.
- W2000674677 hasRelatedWork W2809601010 @default.
- W2000674677 hasVolume "44" @default.
- W2000674677 isParatext "false" @default.
- W2000674677 isRetracted "false" @default.
- W2000674677 magId "2000674677" @default.
- W2000674677 workType "article" @default.