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- W2000674996 abstract "The loss of heterozygosity that is frequently observed at chromosome 8p22→p21.3 in hepatocellular carcinomas (HCC), colorectal cancers (CRC), prostate cancers (PRC), and non-small cell lung cancers (NSCLC), suggests the presence there of one or more tumor suppressor genes associated with development and/or progression of these types of carcinomas. We have constructed a cosmid contig map of the target region by means of Southern hybridization and have isolated 45 exon-like fragments by exon amplification, using cosmid clones derived from three yeast artificial chromosomes (YACs). The map and the exon-like fragments reported here will be useful resources for isolation of the putative tumor suppressor gene(s) as well as other novel genes located in the 8p22→p21.3 region." @default.
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- W2000674996 date "1996-01-01" @default.
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- W2000674996 title "Isolation of 45 exon-like fragments from 8p22→p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomas" @default.
- W2000674996 doi "https://doi.org/10.1159/000134480" @default.
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