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- W2000675384 abstract "Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools have been developed to increase their endogenous tone. In this study, we evaluated whether ECS stimulation could reduce the neurotoxicity of high doses of methamphetamine on the dopamine system. We found that methamphetamine alters the levels of the major endocannabinoids, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) in the striatum, suggesting that the ECS participates in the brain responses to methamphetamine. Δ9-tetrahydrocannabinol (THC), a cannabis-derived agonist of both CB1 and CB2 cannabinoid receptors, or inhibitors of the main enzymes responsible for the degradation of AEA and 2-AG (URB597 and JZL184, respectively), blunted the decrease in striatal protein levels of tyrosine hydroxylase induced by methamphetamine. In addition, antagonists of CB2, but not of CB1, blocked the preventive effects of URB597 and JZL184, suggesting that only the former receptor subtype is engaged in neuroprotection exerted by ECS stimulation. Finally, we found that methamphetamine increases striatal levels of the cytokine tumor necrosis factor alpha, an effect that was blocked by ECS stimulation. Altogether, our results indicate that stimulation of ECS prior to the administration of an overdose of methamphetamine considerably reduces the neurotoxicity of the drug through CB2 receptor activation and highlight a protective function for the ECS against the toxicity induced by drugs and other external insults to the brain. This article is part of the Special Issue entitled ‘CNS Stimulants’." @default.
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- W2000675384 date "2014-12-01" @default.
- W2000675384 modified "2023-10-18" @default.
- W2000675384 title "Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors" @default.
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- W2000675384 cites W1606698275 @default.
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- W2000675384 cites W1928931031 @default.
- W2000675384 cites W1965536242 @default.
- W2000675384 cites W1966849508 @default.
- W2000675384 cites W1972525877 @default.
- W2000675384 cites W1980428699 @default.
- W2000675384 cites W1981323788 @default.
- W2000675384 cites W1987823843 @default.
- W2000675384 cites W1991094289 @default.
- W2000675384 cites W1993018268 @default.
- W2000675384 cites W2003353514 @default.
- W2000675384 cites W2004026924 @default.
- W2000675384 cites W2006321295 @default.
- W2000675384 cites W2008565294 @default.
- W2000675384 cites W2009162487 @default.
- W2000675384 cites W2009732294 @default.
- W2000675384 cites W2011142394 @default.
- W2000675384 cites W2016087136 @default.
- W2000675384 cites W2017522104 @default.
- W2000675384 cites W2018723047 @default.
- W2000675384 cites W2020095459 @default.
- W2000675384 cites W2023590101 @default.
- W2000675384 cites W2024653583 @default.
- W2000675384 cites W2027352187 @default.
- W2000675384 cites W2028312992 @default.
- W2000675384 cites W2037023832 @default.
- W2000675384 cites W2041444093 @default.
- W2000675384 cites W2049028320 @default.
- W2000675384 cites W2051554315 @default.
- W2000675384 cites W2056188558 @default.
- W2000675384 cites W2057111479 @default.
- W2000675384 cites W2062170088 @default.
- W2000675384 cites W2065679828 @default.
- W2000675384 cites W2069068765 @default.
- W2000675384 cites W2074629565 @default.
- W2000675384 cites W2075894678 @default.
- W2000675384 cites W2080649553 @default.
- W2000675384 cites W2083351059 @default.
- W2000675384 cites W2084837506 @default.
- W2000675384 cites W2087371496 @default.
- W2000675384 cites W2087674201 @default.
- W2000675384 cites W2095139799 @default.
- W2000675384 cites W2097747770 @default.
- W2000675384 cites W2098139332 @default.
- W2000675384 cites W2103659596 @default.
- W2000675384 cites W2103903337 @default.
- W2000675384 cites W2109153524 @default.
- W2000675384 cites W2110514788 @default.
- W2000675384 cites W2112755850 @default.
- W2000675384 cites W2124248227 @default.
- W2000675384 cites W2126766019 @default.
- W2000675384 cites W2130014240 @default.
- W2000675384 cites W2133702956 @default.
- W2000675384 cites W2136798984 @default.
- W2000675384 cites W2138563618 @default.
- W2000675384 cites W2140834096 @default.
- W2000675384 cites W2141551684 @default.
- W2000675384 cites W2147069374 @default.
- W2000675384 cites W2150821313 @default.
- W2000675384 cites W2151408038 @default.
- W2000675384 cites W2154345916 @default.
- W2000675384 cites W2155849144 @default.
- W2000675384 cites W2157400187 @default.
- W2000675384 cites W2160291493 @default.
- W2000675384 cites W2161344628 @default.
- W2000675384 cites W2163150813 @default.
- W2000675384 cites W2163320407 @default.
- W2000675384 cites W2163407153 @default.
- W2000675384 cites W2168545748 @default.
- W2000675384 cites W2170388379 @default.
- W2000675384 cites W4241363254 @default.
- W2000675384 cites W4241660517 @default.
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- W2000675384 doi "https://doi.org/10.1016/j.neuropharm.2014.03.014" @default.
- W2000675384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4939842" @default.
- W2000675384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24709540" @default.
- W2000675384 hasPublicationYear "2014" @default.
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