FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000677332> ?p ?o ?g. }

• W2000677332 endingPage "284" @default.
• W2000677332 startingPage "266" @default.
• W2000677332 abstract "This review focuses on antithrombotic therapy for venous thromboembolism and covers a diverse range of topics including a discussion of emerging anticoagulant drugs, a renewed focus on thrombolytic agents for selected patients, and an analysis of the factors leading to adverse events in patients on warfarin, and how to optimize therapy. In Section I Dr. Weitz discusses new anticoagulant drugs focusing on those that are in the advanced stages of development. These will include drugs that (a) target factor VIIa/tissue factor, including tissue factor pathway inhibitor and NAPc2; (b) block factor Xa, including the synthetic pentasaccharide and DX9065a; (c) inhibit factors Va and VIIIa, i.e., activated protein C; and (d) block thrombin, including hirudin, argatroban, bivalirudin and H376/95. Oral formulations of heparin will also be reviewed. In Section II, Dr. Comerota will discuss the use of thrombolysis for selected patients with venous thromboembolism. Fibrinolytic therapy, which has suffered from a high risk/benefit ratio for routine deep venous thrombosis, may have an important role to play in patients with iliofemoral venous thrombosis. Dr. Comerota presents his own results with catheter-directed thrombolytic therapy and the results from a large national registry showing long-term outcomes and the impact on quality of life. In Section III, Dr. Ansell presents a critical analysis of the factors responsible for adverse events with oral anticoagulants and the optimum means of improving outcomes. The poor status of present day anticoagulant management is reviewed and the importance of achieving a high rate of time in therapeutic range, is emphasized. Models of care to optimize outcomes are described, with an emphasis on models that utilize patient self-testing and patient self-management of oral anticoagulation which are considered to be the ultimate in anticoagulation care. The treatment of venous and arterial thromboembolism is undergoing rapid change with respect to the development of new antithrombotic agents, an expanding list of new indications, and new methods of drug delivery and management. In spite of these changes, many of the traditional therapeutics are still with us and continue to play a vital role in the treatment of thromboembolic disease. The following discussion touches on a wide range of therapeutic interventions, from old to new, exploring the status of anticoagulant drug development, describing a new intervention for iliofemoral venous thrombosis, and analyzing the critical factors for safe and effective therapy with oral anticoagulants." @default.
• W2000677332 created "2016-06-24" @default.
• W2000677332 creator A5014841232 @default.
• W2000677332 date "2000-01-01" @default.
• W2000677332 modified "2023-10-12" @default.
• W2000677332 title "Advances in Therapy and the Management of Antithrombotic Drugs for Venous Thromboembolism" @default.
• W2000677332 cites W107120791 @default.
• W2000677332 cites W108782207 @default.
• W2000677332 cites W1486718671 @default.
• W2000677332 cites W1501820105 @default.
• W2000677332 cites W1502744283 @default.
• W2000677332 cites W1521720594 @default.
• W2000677332 cites W1525306910 @default.
• W2000677332 cites W1527418628 @default.
• W2000677332 cites W1561442109 @default.
• W2000677332 cites W1572883374 @default.
• W2000677332 cites W1586488555 @default.
• W2000677332 cites W1601949152 @default.
• W2000677332 cites W1603870906 @default.
• W2000677332 cites W1608358576 @default.
• W2000677332 cites W164623069 @default.
• W2000677332 cites W171420448 @default.
• W2000677332 cites W174314576 @default.
• W2000677332 cites W1836933723 @default.
• W2000677332 cites W1887504786 @default.
• W2000677332 cites W188784659 @default.
• W2000677332 cites W190138522 @default.
• W2000677332 cites W1908166209 @default.
• W2000677332 cites W1931345122 @default.
• W2000677332 cites W1964640624 @default.
• W2000677332 cites W1971587618 @default.
• W2000677332 cites W1974943162 @default.
• W2000677332 cites W1978193003 @default.
• W2000677332 cites W1979288586 @default.
• W2000677332 cites W1979441861 @default.
• W2000677332 cites W1981746689 @default.
• W2000677332 cites W1982885425 @default.
• W2000677332 cites W1987745038 @default.
• W2000677332 cites W1988157797 @default.
• W2000677332 cites W1990850219 @default.
• W2000677332 cites W1992677188 @default.
• W2000677332 cites W1993543402 @default.
• W2000677332 cites W1994894525 @default.
• W2000677332 cites W1996305694 @default.
• W2000677332 cites W1999859798 @default.
• W2000677332 cites W2001411232 @default.
• W2000677332 cites W2001495656 @default.
• W2000677332 cites W2001732339 @default.
• W2000677332 cites W2002576379 @default.
• W2000677332 cites W2004337162 @default.
• W2000677332 cites W2004423916 @default.
• W2000677332 cites W2004719936 @default.
• W2000677332 cites W2006194634 @default.
• W2000677332 cites W2006587134 @default.
• W2000677332 cites W2007303097 @default.
• W2000677332 cites W2012042329 @default.
• W2000677332 cites W2012519169 @default.
• W2000677332 cites W2013547341 @default.
• W2000677332 cites W2024085589 @default.
• W2000677332 cites W2024224171 @default.
• W2000677332 cites W2024597661 @default.
• W2000677332 cites W2029345778 @default.
• W2000677332 cites W2029429532 @default.
• W2000677332 cites W2030099102 @default.
• W2000677332 cites W2032215337 @default.
• W2000677332 cites W2034782781 @default.
• W2000677332 cites W2036681919 @default.
• W2000677332 cites W2037286121 @default.
• W2000677332 cites W2038841215 @default.
• W2000677332 cites W2040111834 @default.
• W2000677332 cites W2040355051 @default.
• W2000677332 cites W2040452288 @default.
• W2000677332 cites W2043976304 @default.
• W2000677332 cites W2044717462 @default.
• W2000677332 cites W2048032060 @default.
• W2000677332 cites W2048550195 @default.
• W2000677332 cites W2051309368 @default.
• W2000677332 cites W2053913188 @default.
• W2000677332 cites W2055085177 @default.
• W2000677332 cites W2057715206 @default.
• W2000677332 cites W2060321368 @default.
• W2000677332 cites W2060578746 @default.
• W2000677332 cites W2063161259 @default.
• W2000677332 cites W2063886493 @default.
• W2000677332 cites W2064219399 @default.
• W2000677332 cites W2064836413 @default.
• W2000677332 cites W2066490209 @default.
• W2000677332 cites W2066822578 @default.
• W2000677332 cites W2068570282 @default.
• W2000677332 cites W2072856207 @default.
• W2000677332 cites W2073695143 @default.
• W2000677332 cites W2073866408 @default.
• W2000677332 cites W2074616500 @default.
• W2000677332 cites W2075196907 @default.
• W2000677332 cites W2077179773 @default.
• W2000677332 cites W2082307469 @default.
• W2000677332 cites W2082378560 @default.
• W2000677332 cites W2085308293 @default.

• next