FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000677548> ?p ?o ?g. }

• W2000677548 endingPage "76" @default.
• W2000677548 startingPage "67" @default.
• W2000677548 abstract "The effects of intravenous injections of alfentanil, fentanyl, phenoperidine or morphine on respiratory and peak inspiratory air flow rate, the diaphragm electromyogram (EMG), the activity recorded extracellularly from respiratory neurones located in the ventral respiratory group and the cardiovascular system were examined in anaesthetized rats. Alfentanil produced dose-dependent changes in peripheral and central respiratory parameters, which were prevented by naloxone pretreatment. Minimal effects were produced on the cardiovascular system. The bradypnoea was principally due to a prolongation of the inspiratory phase and was accompanied by a comparable decrease in the peak inspiratory air flow rate. Alfentanil prolonged the discharge duration of inspiratory neurones such that it still maintained a strict phase correlation with the diaphragm EMG, but changes in firing frequency were inconsistent and negligible. The action on expiratory neuronal discharge was analogous to that on inspiratory neuronal discharge but delayed in onset. Hypotension produced by morphine limited the dose used but the respiratory responses to morphine and other selected narcotic analgesics were otherwise similar to that of alfentanil, differing mainly in time-course and magnitude. From the respiratory parameters assessed, the order of duration of effect was morphine greater than phenoperidine greater than fentanyl greater than alfentanil and the relative potencies were 0.1, 0.5, 2.5 and 1 respectively. The selective prolongation of inspiration and the immediate action on inspiratory neurones suggests that systemically administered narcotic analgesics may alter the mechanisms within the central respiratory rhythm generator which determine the cessation of inspiration." @default.
• W2000677548 created "2016-06-24" @default.
• W2000677548 creator A5009525444 @default.
• W2000677548 creator A5082500003 @default.
• W2000677548 date "1986-09-01" @default.
• W2000677548 modified "2023-10-01" @default.
• W2000677548 title "The effects of alfentanil and selected narcotic analgesics on the rate of action potential discharge of medullary respiratory neurones in anaesthetized rats" @default.
• W2000677548 cites W1922497760 @default.
• W2000677548 cites W1952039887 @default.
• W2000677548 cites W1969020176 @default.
• W2000677548 cites W1970166414 @default.
• W2000677548 cites W1972387806 @default.
• W2000677548 cites W1972956114 @default.
• W2000677548 cites W1973921652 @default.
• W2000677548 cites W1975260962 @default.
• W2000677548 cites W1979245888 @default.
• W2000677548 cites W1979409726 @default.
• W2000677548 cites W1980225657 @default.
• W2000677548 cites W1980468946 @default.
• W2000677548 cites W1987887594 @default.
• W2000677548 cites W1999350764 @default.
• W2000677548 cites W2004726424 @default.
• W2000677548 cites W2005101215 @default.
• W2000677548 cites W2024060499 @default.
• W2000677548 cites W2026816025 @default.
• W2000677548 cites W2034475608 @default.
• W2000677548 cites W2034575949 @default.
• W2000677548 cites W2062174464 @default.
• W2000677548 cites W2068263796 @default.
• W2000677548 cites W2082146758 @default.
• W2000677548 cites W2086309512 @default.
• W2000677548 cites W2094629840 @default.
• W2000677548 cites W2105207075 @default.
• W2000677548 cites W2108823892 @default.
• W2000677548 cites W2252430427 @default.
• W2000677548 cites W2264250284 @default.
• W2000677548 cites W2268539551 @default.
• W2000677548 cites W2400945559 @default.
• W2000677548 cites W4230170762 @default.
• W2000677548 doi "https://doi.org/10.1111/j.1476-5381.1986.tb11121.x" @default.
• W2000677548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917050" @default.
• W2000677548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2879593" @default.
• W2000677548 hasPublicationYear "1986" @default.
• W2000677548 type Work @default.
• W2000677548 sameAs 2000677548 @default.
• W2000677548 citedByCount "16" @default.
• W2000677548 countsByYear W20006775482014 @default.
• W2000677548 countsByYear W20006775482017 @default.
• W2000677548 countsByYear W20006775482018 @default.
• W2000677548 countsByYear W20006775482020 @default.
• W2000677548 countsByYear W20006775482022 @default.
• W2000677548 crossrefType "journal-article" @default.
• W2000677548 hasAuthorship W2000677548A5009525444 @default.
• W2000677548 hasAuthorship W2000677548A5082500003 @default.
• W2000677548 hasBestOaLocation W20006775482 @default.
• W2000677548 hasConcept C121332964 @default.
• W2000677548 hasConcept C126322002 @default.
• W2000677548 hasConcept C157138929 @default.
• W2000677548 hasConcept C164292776 @default.
• W2000677548 hasConcept C170493617 @default.
• W2000677548 hasConcept C24890656 @default.
• W2000677548 hasConcept C2775849661 @default.
• W2000677548 hasConcept C2777389121 @default.
• W2000677548 hasConcept C2777953023 @default.
• W2000677548 hasConcept C2780906327 @default.
• W2000677548 hasConcept C2781063702 @default.
• W2000677548 hasConcept C2781072394 @default.
• W2000677548 hasConcept C2781091344 @default.
• W2000677548 hasConcept C42219234 @default.
• W2000677548 hasConcept C534529494 @default.
• W2000677548 hasConcept C71924100 @default.
• W2000677548 hasConcept C8213797 @default.
• W2000677548 hasConcept C84393581 @default.
• W2000677548 hasConceptScore W2000677548C121332964 @default.
• W2000677548 hasConceptScore W2000677548C126322002 @default.
• W2000677548 hasConceptScore W2000677548C157138929 @default.
• W2000677548 hasConceptScore W2000677548C164292776 @default.
• W2000677548 hasConceptScore W2000677548C170493617 @default.
• W2000677548 hasConceptScore W2000677548C24890656 @default.
• W2000677548 hasConceptScore W2000677548C2775849661 @default.
• W2000677548 hasConceptScore W2000677548C2777389121 @default.
• W2000677548 hasConceptScore W2000677548C2777953023 @default.
• W2000677548 hasConceptScore W2000677548C2780906327 @default.
• W2000677548 hasConceptScore W2000677548C2781063702 @default.
• W2000677548 hasConceptScore W2000677548C2781072394 @default.
• W2000677548 hasConceptScore W2000677548C2781091344 @default.
• W2000677548 hasConceptScore W2000677548C42219234 @default.
• W2000677548 hasConceptScore W2000677548C534529494 @default.
• W2000677548 hasConceptScore W2000677548C71924100 @default.
• W2000677548 hasConceptScore W2000677548C8213797 @default.
• W2000677548 hasConceptScore W2000677548C84393581 @default.
• W2000677548 hasIssue "1" @default.
• W2000677548 hasLocation W20006775481 @default.
• W2000677548 hasLocation W20006775482 @default.
• W2000677548 hasLocation W20006775483 @default.
• W2000677548 hasLocation W20006775484 @default.
• W2000677548 hasOpenAccess W2000677548 @default.
• W2000677548 hasPrimaryLocation W20006775481 @default.

• next