Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000680057> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2000680057 endingPage "27" @default.
- W2000680057 startingPage "24" @default.
- W2000680057 abstract "The rational design of hemocompatible materials requires a mechanistic understanding of activation processes induced at the blood–material interface. Binary self-assembled monolayers of alkyl thiols (SAMs) with various ratios of –CH3 and –COOH terminations were used to study the relevance of hydrophobic and negatively charged surfaces for the initiation of blood coagulation. Platelet adhesion and activation of the intrinsic coagulation pathway scaled with the surface composition: the numbers of adherent platelets were highest on the 100%-CH3 surface whereas the greatest contact activation was seen on 100%-COOH surfaces. In vitro whole blood incubation assays showed, however, that the surfaces exposing either –CH3 or –COOH groups induced comparably low levels of thrombin formation while the surfaces with intermediate contents of both terminating groups had significantly higher values. These results reveal that contact activation and platelet adhesion have a strong synergistic effect on coagulation on blood-contacting materials even though these events in isolation are not sufficient to induce substantial thrombin formation. Successful surface design strategies for hemocompatible materials therefore need to carefully consider the interplay of both processes." @default.
- W2000680057 created "2016-06-24" @default.
- W2000680057 creator A5053946031 @default.
- W2000680057 creator A5070052117 @default.
- W2000680057 creator A5090291054 @default.
- W2000680057 date "1996-05-01" @default.
- W2000680057 modified "2023-09-26" @default.
- W2000680057 title "Interactions of factor XII with platelets and endothelial cells" @default.
- W2000680057 cites W1499670582 @default.
- W2000680057 cites W1504002777 @default.
- W2000680057 cites W1513749471 @default.
- W2000680057 cites W1533112727 @default.
- W2000680057 cites W1541073910 @default.
- W2000680057 cites W1560626372 @default.
- W2000680057 cites W1570407438 @default.
- W2000680057 cites W1584725601 @default.
- W2000680057 cites W1598340191 @default.
- W2000680057 cites W1604352043 @default.
- W2000680057 cites W1917139283 @default.
- W2000680057 cites W1963952199 @default.
- W2000680057 cites W1993140023 @default.
- W2000680057 cites W2053125166 @default.
- W2000680057 cites W2066149593 @default.
- W2000680057 cites W2081753893 @default.
- W2000680057 cites W2139053730 @default.
- W2000680057 cites W2292419927 @default.
- W2000680057 cites W2411238771 @default.
- W2000680057 cites W2464029665 @default.
- W2000680057 cites W41549515 @default.
- W2000680057 doi "https://doi.org/10.1016/0162-3109(96)00004-5" @default.
- W2000680057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8796261" @default.
- W2000680057 hasPublicationYear "1996" @default.
- W2000680057 type Work @default.
- W2000680057 sameAs 2000680057 @default.
- W2000680057 citedByCount "8" @default.
- W2000680057 crossrefType "journal-article" @default.
- W2000680057 hasAuthorship W2000680057A5053946031 @default.
- W2000680057 hasAuthorship W2000680057A5070052117 @default.
- W2000680057 hasAuthorship W2000680057A5090291054 @default.
- W2000680057 hasConcept C12554922 @default.
- W2000680057 hasConcept C126322002 @default.
- W2000680057 hasConcept C178790620 @default.
- W2000680057 hasConcept C185592680 @default.
- W2000680057 hasConcept C203014093 @default.
- W2000680057 hasConcept C2777167447 @default.
- W2000680057 hasConcept C2777292125 @default.
- W2000680057 hasConcept C2778382381 @default.
- W2000680057 hasConcept C2780263894 @default.
- W2000680057 hasConcept C3018697912 @default.
- W2000680057 hasConcept C3018972837 @default.
- W2000680057 hasConcept C71924100 @default.
- W2000680057 hasConcept C84416704 @default.
- W2000680057 hasConcept C86803240 @default.
- W2000680057 hasConcept C89560881 @default.
- W2000680057 hasConceptScore W2000680057C12554922 @default.
- W2000680057 hasConceptScore W2000680057C126322002 @default.
- W2000680057 hasConceptScore W2000680057C178790620 @default.
- W2000680057 hasConceptScore W2000680057C185592680 @default.
- W2000680057 hasConceptScore W2000680057C203014093 @default.
- W2000680057 hasConceptScore W2000680057C2777167447 @default.
- W2000680057 hasConceptScore W2000680057C2777292125 @default.
- W2000680057 hasConceptScore W2000680057C2778382381 @default.
- W2000680057 hasConceptScore W2000680057C2780263894 @default.
- W2000680057 hasConceptScore W2000680057C3018697912 @default.
- W2000680057 hasConceptScore W2000680057C3018972837 @default.
- W2000680057 hasConceptScore W2000680057C71924100 @default.
- W2000680057 hasConceptScore W2000680057C84416704 @default.
- W2000680057 hasConceptScore W2000680057C86803240 @default.
- W2000680057 hasConceptScore W2000680057C89560881 @default.
- W2000680057 hasIssue "1-3" @default.
- W2000680057 hasLocation W20006800571 @default.
- W2000680057 hasLocation W20006800572 @default.
- W2000680057 hasOpenAccess W2000680057 @default.
- W2000680057 hasPrimaryLocation W20006800571 @default.
- W2000680057 hasRelatedWork W1995883770 @default.
- W2000680057 hasRelatedWork W2083194928 @default.
- W2000680057 hasRelatedWork W2117171951 @default.
- W2000680057 hasRelatedWork W2118501220 @default.
- W2000680057 hasRelatedWork W2405392966 @default.
- W2000680057 hasRelatedWork W2460470086 @default.
- W2000680057 hasRelatedWork W3048965591 @default.
- W2000680057 hasRelatedWork W4322757139 @default.
- W2000680057 hasRelatedWork W74287153 @default.
- W2000680057 hasRelatedWork W944021152 @default.
- W2000680057 hasVolume "32" @default.
- W2000680057 isParatext "false" @default.
- W2000680057 isRetracted "false" @default.
- W2000680057 magId "2000680057" @default.
- W2000680057 workType "article" @default.