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- W2000680464 abstract "Cardiovascular (CV) safety concerns are a significant source of drug development attrition in the pharmaceutical industry today. Though current nonclinical testing paradigms have largely prevented catastrophic CV events in Phase I studies, many challenges relating to the inability of current nonclinical safety testing strategies to model patient outcomes persist. Contemporary approaches include a spectrum of evaluations of CV structure and function in a variety of laboratory animal species. These approaches might be improved with a more holistic integration of these evaluations in repeat-dose studies, addition of novel endpoints with greater sensitivity and translational application, and use of more relevant animal models. Particular opportunities present with advances in imaging capabilities applicable to rodent and non-rodent species, technical capabilities for measuring CV function in repeat-dose animal studies, detection and quantitation of microRNAs and wider use of alternative animal models. Strategic application of these novel opportunities considering putative CV risk associated with the molecular drug target as well as inherent risks present in the target patient population could tailor or 'personalize' nonclinical safety assessment as a more translational evaluation. This paper is a call to action for the clinical and nonclinical drug safety communities to assess these opportunities to determine their utility in filling potential gaps in our current cardiovascular safety testing paradigms." @default.
- W2000680464 created "2016-06-24" @default.
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- W2000680464 date "2013-02-01" @default.
- W2000680464 modified "2023-09-26" @default.
- W2000680464 title "Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities" @default.
- W2000680464 cites W117213378 @default.
- W2000680464 cites W119892259 @default.
- W2000680464 cites W1804595442 @default.
- W2000680464 cites W1813333044 @default.
- W2000680464 cites W1956582637 @default.
- W2000680464 cites W1965523675 @default.
- W2000680464 cites W1971726501 @default.
- W2000680464 cites W1976322287 @default.
- W2000680464 cites W1976587747 @default.
- W2000680464 cites W1981890494 @default.
- W2000680464 cites W1982242511 @default.
- W2000680464 cites W1991246546 @default.
- W2000680464 cites W1995528018 @default.
- W2000680464 cites W1996212925 @default.
- W2000680464 cites W1998647454 @default.
- W2000680464 cites W1998990808 @default.
- W2000680464 cites W2000914251 @default.
- W2000680464 cites W2001381530 @default.
- W2000680464 cites W2004081931 @default.
- W2000680464 cites W2004833283 @default.
- W2000680464 cites W2007444496 @default.
- W2000680464 cites W2009052610 @default.
- W2000680464 cites W2012750516 @default.
- W2000680464 cites W2018146294 @default.
- W2000680464 cites W2031853982 @default.
- W2000680464 cites W2032276958 @default.
- W2000680464 cites W2042677320 @default.
- W2000680464 cites W2048254213 @default.
- W2000680464 cites W2048760408 @default.
- W2000680464 cites W2054881124 @default.
- W2000680464 cites W2060079534 @default.
- W2000680464 cites W2062336203 @default.
- W2000680464 cites W2062515250 @default.
- W2000680464 cites W2066115910 @default.
- W2000680464 cites W2068935235 @default.
- W2000680464 cites W2070251374 @default.
- W2000680464 cites W2071721157 @default.
- W2000680464 cites W2071949531 @default.
- W2000680464 cites W2080114744 @default.
- W2000680464 cites W2083501775 @default.
- W2000680464 cites W2090589796 @default.
- W2000680464 cites W2096198355 @default.
- W2000680464 cites W2099359513 @default.
- W2000680464 cites W2100589806 @default.
- W2000680464 cites W2100637763 @default.
- W2000680464 cites W2103224809 @default.
- W2000680464 cites W2104209550 @default.
- W2000680464 cites W2105428420 @default.
- W2000680464 cites W2105891047 @default.
- W2000680464 cites W2107620307 @default.
- W2000680464 cites W2109494884 @default.
- W2000680464 cites W2115557844 @default.
- W2000680464 cites W2116450173 @default.
- W2000680464 cites W2116706974 @default.
- W2000680464 cites W2117659906 @default.
- W2000680464 cites W2120807317 @default.
- W2000680464 cites W2121221492 @default.
- W2000680464 cites W2124427860 @default.
- W2000680464 cites W2125466086 @default.
- W2000680464 cites W2128387764 @default.
- W2000680464 cites W2130433147 @default.
- W2000680464 cites W2131991255 @default.
- W2000680464 cites W2132621122 @default.
- W2000680464 cites W2133153411 @default.
- W2000680464 cites W2135393211 @default.
- W2000680464 cites W2140163830 @default.
- W2000680464 cites W2140740750 @default.
- W2000680464 cites W2145113733 @default.
- W2000680464 cites W2145592978 @default.
- W2000680464 cites W2147349643 @default.
- W2000680464 cites W2150692944 @default.
- W2000680464 cites W2151015374 @default.
- W2000680464 cites W2154312764 @default.
- W2000680464 cites W2154884199 @default.
- W2000680464 cites W2155877918 @default.
- W2000680464 cites W2161027248 @default.
- W2000680464 cites W2163434960 @default.
- W2000680464 cites W2973596107 @default.
- W2000680464 cites W4247240010 @default.