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- W2000681916 abstract "Abstract A specific and sensitive radioimmunoassay of trace amounts of penicillin G in biological fluids is proposed. It is based on the quantitative transformation of penicillin into penicilloyl by rupture of the β-lactam ring of the penicillin molecule, and then the determination of the penicilloyl groups thus formed. Using ϵ-aminocaproic acid as an acceptor which covalently binds with the penicilloyl groups formed, at alkaline pH, allows a complete and reproducible aminolysis of penicillin. The inhibition of the binding to antipenicilloyl antibodies and the association constant appear to be identical whether penicilloyl groups derive from penicillin or are present under standard penicilloyl ϵ-aminocaproate form. Besides this application to the radioimmunoassay of penicillin, the study of the in vitro aminolysis of penicillin should permit better understanding of the complex mechanism of the covalent binding of penicilloyl groups to proteins observed in vivo after penicillin therapy, binding which leads to the allergenic metabolite of penicillin." @default.
- W2000681916 created "2016-06-24" @default.
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- W2000681916 date "1981-07-01" @default.
- W2000681916 modified "2023-09-25" @default.
- W2000681916 title "In vitro penicillin aminolysis: Application to a radioimmunoassay of trace amounts of penicillin" @default.
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- W2000681916 doi "https://doi.org/10.1016/0003-2697(81)90478-4" @default.
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