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• W2000683275 abstract "To investigate whether nitric oxide is involved in the cardiovascular responses mediated via the locus coeruleus, the effects of microinjections of l-arginine and l-glutamate into the locus coeruleus on blood pressure and heart rate were investigated in sodium pentobarbitone-anaesthetized rats. Unilateral microinjection of l-arginine (25, 50 nmol) elicited dose-related depressor (−17±4, −25±4 mmHg) and bradycardic (13±3, 24±6 b.p.m.) effects. Furthermore, these effects were attenuated by prior local microinjection of NG-nitro-l-arginine (40 nmol). Peripheral muscarinic receptor blockade with atropine methyl nitrate (1 mg/kg, i.v.) attenuated the bradycardic but not the depressor responses to l-arginine. l-Glutamate (2 nmol) microinjections also mediated depressor (−27±6 mmHg) and bradycardic (53±23 b.p.m.) effects that were attenuated by microinjections of dizocilpine maleate (1 nmol) into the locus coeruleus. In addition, pretreatment with NG-nitro-l-arginine (40 nmol) also significantly attenuated the depressor response elicited by l-glutamate. These results suggest that nitrergic and glutamatergic pathways are operative within the locus coeruleus to modulate cardiovascular function, and also that a functional interaction may exist between the nitrergic and glutamatergic systems within the rat locus coeruleus." @default.
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• W2000683275 date "1999-06-01" @default.
• W2000683275 modified "2023-10-02" @default.
• W2000683275 title "Nitrergic stimulation of the locus coeruleus modulates blood pressure and heart rate in the anaesthetized rat" @default.
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• W2000683275 doi "https://doi.org/10.1016/s0306-4522(98)00661-7" @default.
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