FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000684456> ?p ?o ?g. }

• W2000684456 endingPage "221" @default.
• W2000684456 startingPage "212" @default.
• W2000684456 abstract "T-2 toxin is one of the most potent trichothecenes, and on exposure causes severe human and animal diseases. We investigated the dose- and time-dependent effect of T-2 toxin on certain biochemical variables, oxidative damage in terms of antioxidant enzyme activity, and gene expression profile in mice. Mice treated intraperitoneally with either 1 LD50 or 2 LD50 dose (5.61 and 11.22 mg/kg body weight, respectively) of T-2 toxin showed significant alterations in hepatic alanine amino transferase, aspartate amino transferase, and lactate dehydrogenase. Significant changes in hepatic lipid peroxidation, depletion of glutathione (GSH), and expression of heat shock protein-70 indicated oxidative damage. We also evaluated the activity of antioxidant enzymes and compared the gene expression profile by quantitative real-time reverse transcriptase–polymerase chain reaction. Except for glutathione reductase (GR), there was a significant increase in activity of glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase at 1 LD50 dose. At 2 LD50 dose, SOD showed decrease in activity, whereas GST, GPx, and catalase showed significant increase. In contrast, gene expression profile showed downregulation in GR, GPx, GST, and catalase at 1 LD50 dose. At 2 LD50 dose except GSH synthetase, all other genes were downregulated. The results clearly show oxidative stress as one of the mechanisms of T-2 toxin-mediated toxicity. © 2009 Wiley Periodicals, Inc. J Biochem Mol Toxicol 23:212–221, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20282" @default.
• W2000684456 created "2016-06-24" @default.
• W2000684456 creator A5030820229 @default.
• W2000684456 creator A5046103625 @default.
• W2000684456 creator A5048166672 @default.
• W2000684456 creator A5088070313 @default.
• W2000684456 date "2009-05-01" @default.
• W2000684456 modified "2023-09-29" @default.
• W2000684456 title "Oxidative damage and gene expression profile of antioxidant enzymes after T-2 toxin exposure in mice" @default.
• W2000684456 cites W1491387523 @default.
• W2000684456 cites W1545899030 @default.
• W2000684456 cites W1546592314 @default.
• W2000684456 cites W1581414347 @default.
• W2000684456 cites W1775749144 @default.
• W2000684456 cites W184607054 @default.
• W2000684456 cites W191793640 @default.
• W2000684456 cites W1964404503 @default.
• W2000684456 cites W1966559024 @default.
• W2000684456 cites W1968335636 @default.
• W2000684456 cites W1981395921 @default.
• W2000684456 cites W1983310681 @default.
• W2000684456 cites W1997467451 @default.
• W2000684456 cites W2004470754 @default.
• W2000684456 cites W2011070432 @default.
• W2000684456 cites W2015231939 @default.
• W2000684456 cites W2026261400 @default.
• W2000684456 cites W2028713528 @default.
• W2000684456 cites W2051092517 @default.
• W2000684456 cites W2069841527 @default.
• W2000684456 cites W2079282623 @default.
• W2000684456 cites W2083628739 @default.
• W2000684456 cites W2086915839 @default.
• W2000684456 cites W2091340154 @default.
• W2000684456 cites W2093814939 @default.
• W2000684456 cites W2107277218 @default.
• W2000684456 cites W2135794349 @default.
• W2000684456 cites W2141819645 @default.
• W2000684456 cites W2151914840 @default.
• W2000684456 cites W2315156311 @default.
• W2000684456 doi "https://doi.org/10.1002/jbt.20282" @default.
• W2000684456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19526462" @default.
• W2000684456 hasPublicationYear "2009" @default.
• W2000684456 type Work @default.
• W2000684456 sameAs 2000684456 @default.
• W2000684456 citedByCount "51" @default.
• W2000684456 countsByYear W20006844562012 @default.
• W2000684456 countsByYear W20006844562013 @default.
• W2000684456 countsByYear W20006844562014 @default.
• W2000684456 countsByYear W20006844562015 @default.
• W2000684456 countsByYear W20006844562016 @default.
• W2000684456 countsByYear W20006844562017 @default.
• W2000684456 countsByYear W20006844562018 @default.
• W2000684456 countsByYear W20006844562019 @default.
• W2000684456 countsByYear W20006844562020 @default.
• W2000684456 countsByYear W20006844562021 @default.
• W2000684456 countsByYear W20006844562022 @default.
• W2000684456 countsByYear W20006844562023 @default.
• W2000684456 crossrefType "journal-article" @default.
• W2000684456 hasAuthorship W2000684456A5030820229 @default.
• W2000684456 hasAuthorship W2000684456A5046103625 @default.
• W2000684456 hasAuthorship W2000684456A5048166672 @default.
• W2000684456 hasAuthorship W2000684456A5088070313 @default.
• W2000684456 hasConcept C153911025 @default.
• W2000684456 hasConcept C158086472 @default.
• W2000684456 hasConcept C165069038 @default.
• W2000684456 hasConcept C181199279 @default.
• W2000684456 hasConcept C185592680 @default.
• W2000684456 hasConcept C2775838275 @default.
• W2000684456 hasConcept C2776151105 @default.
• W2000684456 hasConcept C2776907368 @default.
• W2000684456 hasConcept C2778004101 @default.
• W2000684456 hasConcept C2778760513 @default.
• W2000684456 hasConcept C2778979269 @default.
• W2000684456 hasConcept C2780829032 @default.
• W2000684456 hasConcept C538909803 @default.
• W2000684456 hasConcept C55493867 @default.
• W2000684456 hasConcept C86803240 @default.
• W2000684456 hasConceptScore W2000684456C153911025 @default.
• W2000684456 hasConceptScore W2000684456C158086472 @default.
• W2000684456 hasConceptScore W2000684456C165069038 @default.
• W2000684456 hasConceptScore W2000684456C181199279 @default.
• W2000684456 hasConceptScore W2000684456C185592680 @default.
• W2000684456 hasConceptScore W2000684456C2775838275 @default.
• W2000684456 hasConceptScore W2000684456C2776151105 @default.
• W2000684456 hasConceptScore W2000684456C2776907368 @default.
• W2000684456 hasConceptScore W2000684456C2778004101 @default.
• W2000684456 hasConceptScore W2000684456C2778760513 @default.
• W2000684456 hasConceptScore W2000684456C2778979269 @default.
• W2000684456 hasConceptScore W2000684456C2780829032 @default.
• W2000684456 hasConceptScore W2000684456C538909803 @default.
• W2000684456 hasConceptScore W2000684456C55493867 @default.
• W2000684456 hasConceptScore W2000684456C86803240 @default.
• W2000684456 hasIssue "3" @default.
• W2000684456 hasLocation W20006844561 @default.
• W2000684456 hasLocation W20006844562 @default.
• W2000684456 hasOpenAccess W2000684456 @default.
• W2000684456 hasPrimaryLocation W20006844561 @default.
• W2000684456 hasRelatedWork W1997751979 @default.

• next