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- W2000684473 abstract "The effects of caffeine on the outer hair cells (OHCs) freshly dissociated from guinea-pig cochlea were investigated with the whole-cell patch-clamp technique, in both the conventional and the nystatin perforated patch-clamp configurations under voltage-clamp condition. Application of caffeine (> 1 mM for 10–30 s) induced an inward current (Icaffeine) with decrease of conductance in a dose-dependent manner at a holding potential (VH) of −60 mV. The reversal potential ofIcaffeine (Ecaffeine) was close to the K+ equilibrium potential. TheIcaffeine was not affected by Ca2+-free external solution. The internal perfusion of the Ca2+ chelator BAPTA had no effect onIcaffeine. TheIcaffeine was not modulated by the external application of H-8 or staurosporine and by the internal perfusion of GDP-βS. The amplitude ofIcaffeine was the largest at the basal region of OHCs when caffeine was locally applied by the ‘puffer’ method. These results suggest that caffeine induces a decrease in membrane potassium conductance of the OHCs mainly at the basal region without mediating the intracellular signaling pathway." @default.
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- W2000684473 date "1995-04-01" @default.
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- W2000684473 title "Caffeine rapidly decreases potassium conductance of dissociated outer hair cells of guinea-pig cochlea" @default.
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- W2000684473 doi "https://doi.org/10.1016/0006-8993(95)00121-6" @default.
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