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- W2000684676 abstract "Adrenalectomized rats were implanted with pellets containing corticosterone in proportions varying from 0% to 100%, plus cholesterol. Stable levels of plasma corticosterone resulted, varying from close to zero (I) to physiologic (II) to supraphysiologic (III). Whole body protein synthesis (S) was measured during fasting by a technique involving injection of [1-14C]-leucine, analysis of expired air for 14CO2, and measurement of urinary excretion of urea N plus ammonia N (C). Whole body breakdown (B) during fasting was calculated as the sum of S and C. C rose progressively from I to III, but fractional oxidation of 14C leucine was lowest in II. Both S and B were markedly reduced in I and maximal in II. In III, S fell but B remained high. Thus variations in glucocorticoid levels above and below physiologic exert profound effects on leucine oxidation and protein turnover, involving effects on both synthesis and breakdown." @default.
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- W2000684676 date "1991-12-01" @default.
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- W2000684676 title "Effect of corticosterone administration at varying levels on leucine oxidation and whole body protein synthesis and breakdown in adrenalectomized rats" @default.
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- W2000684676 doi "https://doi.org/10.1016/0026-0495(91)90026-s" @default.
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