FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000686891> ?p ?o ?g. }

• W2000686891 endingPage "75" @default.
• W2000686891 startingPage "69" @default.
• W2000686891 abstract "Several proteins that are important components of the calcium/phospholipid second messenger system (e.g. phospholipase C, protein kinase C, myristoylated alanine-rich C kinase substrate (MARCKS) and pp60src) contain clusters of basic residues that can interact with acidic lipids on the cytoplasmic surface of plasma membranes. We have studied the membrane binding of MARCKS and pp60src, peptides that mimic the basic regions of these proteins, and simple model peptides. Specifically, we determined how the binding of these model peptides depends on (1) the number of basic residues in the peptide (2) the fraction of acidic lipids in the membrane (3) the ionic strength of the solution (4) the chemical nature of the basic residues (Arg versus Lys) and the acidic phospholipids [phosphatidylglycerol (PG) versus phosphatidylserine (PS)] (5) the pressure and (6) the temperature. The results are consistent with a simple theoretical model: each basic residue in a peptide binds independently to an acidic lipid with an intrinsic microscopic association constant of 1-10 M-1 (binding energy congruent to 1 kcal/mol). The binding is described with a mass action formalism and the non-specific electrostatic accumulation of the peptides in the aqueous diffuse double layer is described with the Gouy-Chapman theory. This Gouy-Chapman/mass action model accounts surprisingly well for the sigmoidal dependence of binding on the percentage of acidic lipids in the membrane (apparent co-operativity or Hill coefficient > 1); the model assumes that the multivalent basic peptides bind > 1 acidic lipids and thus induce or stabilize domain formation." @default.
• W2000686891 created "2016-06-24" @default.
• W2000686891 creator A5038598245 @default.
• W2000686891 creator A5045654078 @default.
• W2000686891 creator A5062778264 @default.
• W2000686891 creator A5078548844 @default.
• W2000686891 date "1995-01-01" @default.
• W2000686891 modified "2023-10-09" @default.
• W2000686891 title "Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?" @default.
• W2000686891 cites W130559879 @default.
• W2000686891 cites W1519639344 @default.
• W2000686891 cites W1537076792 @default.
• W2000686891 cites W1556656117 @default.
• W2000686891 cites W1565185374 @default.
• W2000686891 cites W157808733 @default.
• W2000686891 cites W1588018069 @default.
• W2000686891 cites W1593795070 @default.
• W2000686891 cites W1593910029 @default.
• W2000686891 cites W1600300278 @default.
• W2000686891 cites W1603607026 @default.
• W2000686891 cites W1964011658 @default.
• W2000686891 cites W1967689256 @default.
• W2000686891 cites W1968453135 @default.
• W2000686891 cites W1971809347 @default.
• W2000686891 cites W1976319209 @default.
• W2000686891 cites W1980166477 @default.
• W2000686891 cites W1985899857 @default.
• W2000686891 cites W1987142860 @default.
• W2000686891 cites W2000774142 @default.
• W2000686891 cites W2008264122 @default.
• W2000686891 cites W2010207338 @default.
• W2000686891 cites W2011500156 @default.
• W2000686891 cites W2011756605 @default.
• W2000686891 cites W2012490119 @default.
• W2000686891 cites W2019861301 @default.
• W2000686891 cites W2022467870 @default.
• W2000686891 cites W2022711538 @default.
• W2000686891 cites W2024389606 @default.
• W2000686891 cites W2026495415 @default.
• W2000686891 cites W2029997845 @default.
• W2000686891 cites W2041347732 @default.
• W2000686891 cites W2047184374 @default.
• W2000686891 cites W2048497567 @default.
• W2000686891 cites W2058149897 @default.
• W2000686891 cites W2059626243 @default.
• W2000686891 cites W2061292285 @default.
• W2000686891 cites W2061942801 @default.
• W2000686891 cites W2064332862 @default.
• W2000686891 cites W2073737852 @default.
• W2000686891 cites W2080127910 @default.
• W2000686891 cites W2083248905 @default.
• W2000686891 cites W2094987877 @default.
• W2000686891 cites W2114257122 @default.
• W2000686891 cites W2128859932 @default.
• W2000686891 cites W2136702130 @default.
• W2000686891 cites W2162069529 @default.
• W2000686891 cites W2179142653 @default.
• W2000686891 cites W2179964627 @default.
• W2000686891 cites W4235326831 @default.
• W2000686891 doi "https://doi.org/10.3109/09687689509038498" @default.
• W2000686891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7767386" @default.
• W2000686891 hasPublicationYear "1995" @default.
• W2000686891 type Work @default.
• W2000686891 sameAs 2000686891 @default.
• W2000686891 citedByCount "39" @default.
• W2000686891 countsByYear W20006868912016 @default.
• W2000686891 crossrefType "journal-article" @default.
• W2000686891 hasAuthorship W2000686891A5038598245 @default.
• W2000686891 hasAuthorship W2000686891A5045654078 @default.
• W2000686891 hasAuthorship W2000686891A5062778264 @default.
• W2000686891 hasAuthorship W2000686891A5078548844 @default.
• W2000686891 hasConcept C12554922 @default.
• W2000686891 hasConcept C185592680 @default.
• W2000686891 hasConcept C2776330855 @default.
• W2000686891 hasConcept C2778918659 @default.
• W2000686891 hasConcept C2779281246 @default.
• W2000686891 hasConcept C2780726299 @default.
• W2000686891 hasConcept C2780780085 @default.
• W2000686891 hasConcept C2781338088 @default.
• W2000686891 hasConcept C41625074 @default.
• W2000686891 hasConcept C55493867 @default.
• W2000686891 hasConcept C71240020 @default.
• W2000686891 hasConcept C77207865 @default.
• W2000686891 hasConcept C86803240 @default.
• W2000686891 hasConceptScore W2000686891C12554922 @default.
• W2000686891 hasConceptScore W2000686891C185592680 @default.
• W2000686891 hasConceptScore W2000686891C2776330855 @default.
• W2000686891 hasConceptScore W2000686891C2778918659 @default.
• W2000686891 hasConceptScore W2000686891C2779281246 @default.
• W2000686891 hasConceptScore W2000686891C2780726299 @default.
• W2000686891 hasConceptScore W2000686891C2780780085 @default.
• W2000686891 hasConceptScore W2000686891C2781338088 @default.
• W2000686891 hasConceptScore W2000686891C41625074 @default.
• W2000686891 hasConceptScore W2000686891C55493867 @default.
• W2000686891 hasConceptScore W2000686891C71240020 @default.
• W2000686891 hasConceptScore W2000686891C77207865 @default.
• W2000686891 hasConceptScore W2000686891C86803240 @default.
• W2000686891 hasIssue "1" @default.

• next