Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000687519> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2000687519 endingPage "1719" @default.
- W2000687519 startingPage "1709" @default.
- W2000687519 abstract "Leukotrienes (LTs) are involved in many inflammatory conditions including gastric damage induced by nonsteroidal anti-inflammatory drugs. Although LTs stimulate acid secretion, the effect they exert on pepsinogen secretion is unknown. The aim of this study was to investigate whether LTs stimulate pepsinogen secretion by isolated chief cells and to identify the intracellular messengers that mediate this action.Isolated chief cells were incubated with concentrations of LTB4, LTC4, LTD4, or LTE4 ranging from 0.1 pmol/L to 10 mumol/L, and pepsinogen release, intracellular calcium and inositol(1,4,5)-trisphosphate (IP3) concentrations were measured. Nitric oxide generation was determined by the amount of citrulline generated during incubation.All four LTs caused a concentration-dependent stimulation of pepsinogen secretion with 50% effective concentration of 0.05-0.1 nmol/L and a dose-dependent increase in cytoplasmic free calcium and IP3 concentration. The LTB4 and LTD4 antagonists caused selective, concentration-dependent inhibition of LTB4- and LTD4-induced pepsinogen secretion, calcium mobilization, and IP3 generation. All four LTs increased NO generation, and the effect was inhibited by LTB4 and LTD4 antagonists and an NO synthase inhibitor NG-monomethyl-L-arginine and reversed by L-arginine. NG-monomethyl-L-arginine caused a 50%-60% reduction of LT-induced pepsinogen release. Each of the four LTs caused a fivefold increase in 5'-cyclic guanosine monophosphate.LTs are powerful stimulators of pepsinogen secretion in isolated chief cells and act via occupancy of specific cell-surface receptors." @default.
- W2000687519 created "2016-06-24" @default.
- W2000687519 creator A5053616013 @default.
- W2000687519 creator A5057720130 @default.
- W2000687519 creator A5073371586 @default.
- W2000687519 creator A5082173292 @default.
- W2000687519 date "1995-06-01" @default.
- W2000687519 modified "2023-09-30" @default.
- W2000687519 title "Leukotrienes stimulate pepsinogen secretion from guinea pig gastric chief cells by a nitric oxide-dependent pathway" @default.
- W2000687519 cites W1499398296 @default.
- W2000687519 cites W1514380919 @default.
- W2000687519 cites W1535298549 @default.
- W2000687519 cites W1535670154 @default.
- W2000687519 cites W1540054340 @default.
- W2000687519 cites W1558480191 @default.
- W2000687519 cites W1591067042 @default.
- W2000687519 cites W1891823702 @default.
- W2000687519 cites W1954825632 @default.
- W2000687519 cites W1969706311 @default.
- W2000687519 cites W1974144918 @default.
- W2000687519 cites W1980166477 @default.
- W2000687519 cites W1988812540 @default.
- W2000687519 cites W2007737411 @default.
- W2000687519 cites W2011220321 @default.
- W2000687519 cites W2024864508 @default.
- W2000687519 cites W2029077000 @default.
- W2000687519 cites W2046262741 @default.
- W2000687519 cites W2048635427 @default.
- W2000687519 cites W2052777784 @default.
- W2000687519 cites W2054036741 @default.
- W2000687519 cites W2068858849 @default.
- W2000687519 doi "https://doi.org/10.1016/0016-5085(95)90132-9" @default.
- W2000687519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7768375" @default.
- W2000687519 hasPublicationYear "1995" @default.
- W2000687519 type Work @default.
- W2000687519 sameAs 2000687519 @default.
- W2000687519 citedByCount "21" @default.
- W2000687519 countsByYear W20006875192012 @default.
- W2000687519 countsByYear W20006875192014 @default.
- W2000687519 countsByYear W20006875192015 @default.
- W2000687519 crossrefType "journal-article" @default.
- W2000687519 hasAuthorship W2000687519A5053616013 @default.
- W2000687519 hasAuthorship W2000687519A5057720130 @default.
- W2000687519 hasAuthorship W2000687519A5073371586 @default.
- W2000687519 hasAuthorship W2000687519A5082173292 @default.
- W2000687519 hasBestOaLocation W20006875191 @default.
- W2000687519 hasConcept C1122143 @default.
- W2000687519 hasConcept C126322002 @default.
- W2000687519 hasConcept C134018914 @default.
- W2000687519 hasConcept C181080969 @default.
- W2000687519 hasConcept C185592680 @default.
- W2000687519 hasConcept C2779422922 @default.
- W2000687519 hasConcept C2781443798 @default.
- W2000687519 hasConcept C49039625 @default.
- W2000687519 hasConcept C519063684 @default.
- W2000687519 hasConcept C519581460 @default.
- W2000687519 hasConcept C55493867 @default.
- W2000687519 hasConcept C66595182 @default.
- W2000687519 hasConcept C71924100 @default.
- W2000687519 hasConcept C79879829 @default.
- W2000687519 hasConcept C86803240 @default.
- W2000687519 hasConceptScore W2000687519C1122143 @default.
- W2000687519 hasConceptScore W2000687519C126322002 @default.
- W2000687519 hasConceptScore W2000687519C134018914 @default.
- W2000687519 hasConceptScore W2000687519C181080969 @default.
- W2000687519 hasConceptScore W2000687519C185592680 @default.
- W2000687519 hasConceptScore W2000687519C2779422922 @default.
- W2000687519 hasConceptScore W2000687519C2781443798 @default.
- W2000687519 hasConceptScore W2000687519C49039625 @default.
- W2000687519 hasConceptScore W2000687519C519063684 @default.
- W2000687519 hasConceptScore W2000687519C519581460 @default.
- W2000687519 hasConceptScore W2000687519C55493867 @default.
- W2000687519 hasConceptScore W2000687519C66595182 @default.
- W2000687519 hasConceptScore W2000687519C71924100 @default.
- W2000687519 hasConceptScore W2000687519C79879829 @default.
- W2000687519 hasConceptScore W2000687519C86803240 @default.
- W2000687519 hasIssue "6" @default.
- W2000687519 hasLocation W20006875191 @default.
- W2000687519 hasLocation W20006875192 @default.
- W2000687519 hasOpenAccess W2000687519 @default.
- W2000687519 hasPrimaryLocation W20006875191 @default.
- W2000687519 hasRelatedWork W1965692775 @default.
- W2000687519 hasRelatedWork W1983315707 @default.
- W2000687519 hasRelatedWork W2003842308 @default.
- W2000687519 hasRelatedWork W2020884724 @default.
- W2000687519 hasRelatedWork W2064236298 @default.
- W2000687519 hasRelatedWork W2090408064 @default.
- W2000687519 hasRelatedWork W2095093072 @default.
- W2000687519 hasRelatedWork W2161296685 @default.
- W2000687519 hasRelatedWork W2172131010 @default.
- W2000687519 hasRelatedWork W4255681344 @default.
- W2000687519 hasVolume "108" @default.
- W2000687519 isParatext "false" @default.
- W2000687519 isRetracted "false" @default.
- W2000687519 magId "2000687519" @default.
- W2000687519 workType "article" @default.