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• W2000687543 abstract "Previous transgenic-reporter and targeted-deletion studies indicate that the subset-specific expression of CD8αβ heterodimers is controlled by multiple enhancer activities, since no silencer elements had been found within the locus. We have identified such a silencer as L2a, a previously characterized ∼220 bp nuclear matrix associating region (MAR) located ∼4.5 kb upstream of CD8α. L2a transgenes driven by the E8I enhancer showed no reporter expression in thymic subsets or T cells in splenic, inguinal and mesenteric lymph node peripheral T cells. Deletion of L2a resulted in significant reporter de-repression, even in the CD4+CD8+ double positive (DP) thymocyte population. L2a contains binding sites for two MAR-interacting proteins, SATB1 and CDP. We found that that binding of these factors was markedly influenced by the content and spacing of L2a sub-motifs (L and S) and that SATB1 binds preferentially to the L motif both in vitro and in vivo. A small fraction of the transgenic CD8 single positive (SP) thymocytes and peripheral CD8+ T cells bypassed L2a-silencing to give rise to variegated expression of the transgenic reporter. Crossing the L2a-containing transgene onto a SATB1 knockdown background enhanced variegated expression, suggesting that SATB1 is critical in overcoming L2a-silenced transcription." @default.
• W2000687543 created "2016-06-24" @default.
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• W2000687543 date "2010-11-01" @default.
• W2000687543 modified "2023-09-26" @default.
• W2000687543 title "The L2a element is a mouse CD8 silencer that interacts with MAR-binding proteins SATB1 and CDP" @default.
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• W2000687543 doi "https://doi.org/10.1016/j.molimm.2010.08.014" @default.
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