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- W2000687555 endingPage "1262" @default.
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- W2000687555 abstract "The non-mevalonate pathway constitutes a source of novel drug targets. This biosynthetic route is essential for pathogens but is absent in humans. Our systematic evaluation of the druggability of all enzymes provides a convenient way of selecting targets that should be most easily inhibited by small-molecule drugs. We found that not every target is equally druggable and we identified novel, druggable, potentially allosteric sites. These results should accelerate the development of anti-infective drugs with a novel mode of action, which are needed ever more urgently in light of the rapid emergence of drug-resistant strains." @default.
- W2000687555 created "2016-06-24" @default.
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- W2000687555 date "2013-12-01" @default.
- W2000687555 modified "2023-10-16" @default.
- W2000687555 title "Druggability of the enzymes of the non-mevalonate-pathway" @default.
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- W2000687555 doi "https://doi.org/10.1016/j.drudis.2013.07.003" @default.
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