Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000687571> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2000687571 endingPage "e85194" @default.
- W2000687571 startingPage "e85194" @default.
- W2000687571 abstract "An MRI biomarker for Parkinsonism has long been sought, but almost all attempts at conventional field strengths have proved unsatisfactory, since patients and controls are not separated. The exception is Spin-Lattice Distribution MRI (SLD-MRI), a technique which detects changes in the substantia nigra (SN) due to changes in the spin-lattice relaxation time, T1. This easily separates patients with Parkinson's disease (PD) from control subjects at 1.5 Tesla, suggesting that it may be sensitive to presymptomatic disease. SLD-MRI demonstrates a topography of signal change within the SN which is the same as the known topography of pathological change, where the lateral portions of the nucleus are more affected than the medial. In a further step towards its validation, we apply SLD-MRI to a disease control, Progressive Supranuclear Palsy (PSP), the most common of the atypical forms of Parkinsonism. In PSP the topography of pathological change in the SN is reversed. We therefore hypothesized that PSP would show a topography of SLD-MRI signal change in the SN that is the reverse of PD (i.e. the medial portion is more affected than the lateral). All 7 patients showed such a topography of MR signal, and all patients were separated from control subjects. Although this is a step toward validation of SLD-MRI with respect to sensitivity and disease specificity, nevertheless we stress that this is a pilot project only. Validation will only be possible when comparing larger cohorts of PSP, PD and control subjects." @default.
- W2000687571 created "2016-06-24" @default.
- W2000687571 creator A5045153735 @default.
- W2000687571 creator A5058311965 @default.
- W2000687571 creator A5072945022 @default.
- W2000687571 creator A5076530179 @default.
- W2000687571 date "2014-01-28" @default.
- W2000687571 modified "2023-10-16" @default.
- W2000687571 title "Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study" @default.
- W2000687571 cites W1520259015 @default.
- W2000687571 cites W1991344285 @default.
- W2000687571 cites W2004756181 @default.
- W2000687571 cites W2011843196 @default.
- W2000687571 cites W2025239936 @default.
- W2000687571 cites W2074487468 @default.
- W2000687571 cites W2083255557 @default.
- W2000687571 cites W2090541644 @default.
- W2000687571 cites W2092462980 @default.
- W2000687571 cites W2125378634 @default.
- W2000687571 doi "https://doi.org/10.1371/journal.pone.0085194" @default.
- W2000687571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3904838" @default.
- W2000687571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24489655" @default.
- W2000687571 hasPublicationYear "2014" @default.
- W2000687571 type Work @default.
- W2000687571 sameAs 2000687571 @default.
- W2000687571 citedByCount "3" @default.
- W2000687571 countsByYear W20006875712016 @default.
- W2000687571 countsByYear W20006875712017 @default.
- W2000687571 countsByYear W20006875712021 @default.
- W2000687571 crossrefType "journal-article" @default.
- W2000687571 hasAuthorship W2000687571A5045153735 @default.
- W2000687571 hasAuthorship W2000687571A5058311965 @default.
- W2000687571 hasAuthorship W2000687571A5072945022 @default.
- W2000687571 hasAuthorship W2000687571A5076530179 @default.
- W2000687571 hasBestOaLocation W20006875711 @default.
- W2000687571 hasConcept C126838900 @default.
- W2000687571 hasConcept C142724271 @default.
- W2000687571 hasConcept C143409427 @default.
- W2000687571 hasConcept C207886595 @default.
- W2000687571 hasConcept C2776477761 @default.
- W2000687571 hasConcept C2776525014 @default.
- W2000687571 hasConcept C2779134260 @default.
- W2000687571 hasConcept C2779734285 @default.
- W2000687571 hasConcept C2780938664 @default.
- W2000687571 hasConcept C71924100 @default.
- W2000687571 hasConceptScore W2000687571C126838900 @default.
- W2000687571 hasConceptScore W2000687571C142724271 @default.
- W2000687571 hasConceptScore W2000687571C143409427 @default.
- W2000687571 hasConceptScore W2000687571C207886595 @default.
- W2000687571 hasConceptScore W2000687571C2776477761 @default.
- W2000687571 hasConceptScore W2000687571C2776525014 @default.
- W2000687571 hasConceptScore W2000687571C2779134260 @default.
- W2000687571 hasConceptScore W2000687571C2779734285 @default.
- W2000687571 hasConceptScore W2000687571C2780938664 @default.
- W2000687571 hasConceptScore W2000687571C71924100 @default.
- W2000687571 hasIssue "1" @default.
- W2000687571 hasLocation W20006875711 @default.
- W2000687571 hasLocation W20006875712 @default.
- W2000687571 hasLocation W20006875713 @default.
- W2000687571 hasLocation W20006875714 @default.
- W2000687571 hasLocation W20006875715 @default.
- W2000687571 hasOpenAccess W2000687571 @default.
- W2000687571 hasPrimaryLocation W20006875711 @default.
- W2000687571 hasRelatedWork W2016926246 @default.
- W2000687571 hasRelatedWork W2077823528 @default.
- W2000687571 hasRelatedWork W2122990772 @default.
- W2000687571 hasRelatedWork W2318530625 @default.
- W2000687571 hasRelatedWork W2413510344 @default.
- W2000687571 hasRelatedWork W2501550554 @default.
- W2000687571 hasRelatedWork W2586779011 @default.
- W2000687571 hasRelatedWork W2625127552 @default.
- W2000687571 hasRelatedWork W3114867632 @default.
- W2000687571 hasRelatedWork W4211123396 @default.
- W2000687571 hasVolume "9" @default.
- W2000687571 isParatext "false" @default.
- W2000687571 isRetracted "false" @default.
- W2000687571 magId "2000687571" @default.
- W2000687571 workType "article" @default.