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• W2000689075 abstract "In the Lewis rat, the T lymphocyte response to guinea pig myelin basic protein (MBP) is focused almost exclusively on epitopes nested in the MBP peptide sequence p68 – 88, and is dominated by T cell receptors (TCR) using Vβ8.2 gene elements, together with short N(D)N regions. Here we analyzed MBP-specific TCR from Lewis T cells differentiating in chimeric thymuses of Lewis rat/SCID mouse chimeras, in the absence of an intact rat thymic microen vironment (SCIDFL mice). In these T cells, the TCR Vβ repertoire is broad, N(D)N regions are significantly longer, and contain regular rates of template-independent N nucleotides. In striking contrast, a Vβ8.2 biased TCR repertoire and few N-region inserts are seen in p68 – 88-specific, Lewis rat-derived T cells differentiating in the complete rat thymic microen vironment provided by chimeric SCID mice bearing embryonic Lewis thymus grafts (SCIDFL/FT mice). A T cell repertoire resembling the one in SCIDFL mice is used by T cells of intact Lewis rats following immunization with a truncated epitope of MBP, p69 – 86. Also this selection generates a broad TCR Vβ pattern with long N(D)N regions, and higher numbers of N nucleotides. These results show that both intrathymic repertoire selection, and extrathymic peptide priming exert profound effects on the TCR usage in the anti-MBP response of Lewis rats." @default.
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• W2000689075 date "1998-05-01" @default.
• W2000689075 modified "2023-09-26" @default.
• W2000689075 title "The myelin basic protein-specific T cell repertoire in Lewis rats: T cell receptor diversity is influenced both by intrathymic milieu and by extrathymic peptide presentation" @default.
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• W2000689075 doi "https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1499::aid-immu1499>3.0.co;2-s" @default.
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