Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000689364> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2000689364 abstract "The role of the glucocorticoid hormones in mediating the accelerated hepatic amino acid transport that is characteristic of endotoxemia was investigated. To determine the role of these steroid hormones, rats that received endotoxin (LPS) were pretreated with the glucocorticoid receptor antagonist RU38486. The activities of the Na(+)-dependent amino acid transport systems A, ASC, and N and the Na(+)-independent systems L, y+, n, b0,+, and asc in hepatic plasma membrane vesicles were measured 4 hr after exposure to LPS. Endotoxin treatment resulted in time- and dose-dependent 5-fold (System A), 2.5-fold (System N), 2.6-fold (System ASC), and 2-fold (System y+ and b0,+) increases in transport activity attributable to an increase in carrier Vmax. The activities of L, asc, and n were unchanged by LPS administration. Pretreatment of endotoxemic animals with RU38486 attenuated the LPS-induced enhancement in transport activity by 20-60% by diminishing carrier Vmax, with no effect on transport Km. We conclude that the marked increase in hepatic amino acid transport activity that occurs during endotoxemia requires participation of the glucocorticoid hormones." @default.
- W2000689364 created "2016-06-24" @default.
- W2000689364 creator A5017332423 @default.
- W2000689364 creator A5045005400 @default.
- W2000689364 creator A5054499110 @default.
- W2000689364 creator A5090859723 @default.
- W2000689364 date "1995-06-01" @default.
- W2000689364 modified "2023-10-18" @default.
- W2000689364 title "Attenuation of the Endotoxin-Stimulated Increase in Hepatic Amino Acid Transport with a Glucocorticoid Receptor Antagonist" @default.
- W2000689364 doi "https://doi.org/10.1006/jsre.1995.1109" @default.
- W2000689364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7791348" @default.
- W2000689364 hasPublicationYear "1995" @default.
- W2000689364 type Work @default.
- W2000689364 sameAs 2000689364 @default.
- W2000689364 citedByCount "12" @default.
- W2000689364 countsByYear W20006893642013 @default.
- W2000689364 countsByYear W20006893642017 @default.
- W2000689364 crossrefType "journal-article" @default.
- W2000689364 hasAuthorship W2000689364A5017332423 @default.
- W2000689364 hasAuthorship W2000689364A5045005400 @default.
- W2000689364 hasAuthorship W2000689364A5054499110 @default.
- W2000689364 hasAuthorship W2000689364A5090859723 @default.
- W2000689364 hasConcept C126322002 @default.
- W2000689364 hasConcept C134018914 @default.
- W2000689364 hasConcept C170493617 @default.
- W2000689364 hasConcept C185592680 @default.
- W2000689364 hasConcept C2776885963 @default.
- W2000689364 hasConcept C2778122271 @default.
- W2000689364 hasConcept C2780004078 @default.
- W2000689364 hasConcept C2780841215 @default.
- W2000689364 hasConcept C515207424 @default.
- W2000689364 hasConcept C55493867 @default.
- W2000689364 hasConcept C59493245 @default.
- W2000689364 hasConcept C71315377 @default.
- W2000689364 hasConcept C71924100 @default.
- W2000689364 hasConcept C86803240 @default.
- W2000689364 hasConceptScore W2000689364C126322002 @default.
- W2000689364 hasConceptScore W2000689364C134018914 @default.
- W2000689364 hasConceptScore W2000689364C170493617 @default.
- W2000689364 hasConceptScore W2000689364C185592680 @default.
- W2000689364 hasConceptScore W2000689364C2776885963 @default.
- W2000689364 hasConceptScore W2000689364C2778122271 @default.
- W2000689364 hasConceptScore W2000689364C2780004078 @default.
- W2000689364 hasConceptScore W2000689364C2780841215 @default.
- W2000689364 hasConceptScore W2000689364C515207424 @default.
- W2000689364 hasConceptScore W2000689364C55493867 @default.
- W2000689364 hasConceptScore W2000689364C59493245 @default.
- W2000689364 hasConceptScore W2000689364C71315377 @default.
- W2000689364 hasConceptScore W2000689364C71924100 @default.
- W2000689364 hasConceptScore W2000689364C86803240 @default.
- W2000689364 hasLocation W20006893641 @default.
- W2000689364 hasLocation W20006893642 @default.
- W2000689364 hasOpenAccess W2000689364 @default.
- W2000689364 hasPrimaryLocation W20006893641 @default.
- W2000689364 hasRelatedWork W1981044771 @default.
- W2000689364 hasRelatedWork W2000954890 @default.
- W2000689364 hasRelatedWork W2004322984 @default.
- W2000689364 hasRelatedWork W2031083269 @default.
- W2000689364 hasRelatedWork W2034583712 @default.
- W2000689364 hasRelatedWork W2036237097 @default.
- W2000689364 hasRelatedWork W2124988877 @default.
- W2000689364 hasRelatedWork W2213857395 @default.
- W2000689364 hasRelatedWork W2989838574 @default.
- W2000689364 hasRelatedWork W2022381224 @default.
- W2000689364 isParatext "false" @default.
- W2000689364 isRetracted "false" @default.
- W2000689364 magId "2000689364" @default.
- W2000689364 workType "article" @default.