FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000690501> ?p ?o ?g. }

• W2000690501 endingPage "918" @default.
• W2000690501 startingPage "911" @default.
• W2000690501 abstract "Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the US. The majority (~85%) of GISTs possess gain-of-function mutations in KIT or PDGFRA, causing constitutive activation of the kinase receptor. GIST management has been transformed by the identification of tumor driver mutations leading to unprecedented disease control of advanced GIST with the introduction of imatinib mesylate (IM). Despite IM's efficacy, most patients experience primary and/or secondary resistance within 2 y of treatment. Additional therapies and methods to optimize screening of novel approaches in preclinical studies are warranted. Clinically, treatment efficacy is typically assessed using Response Evaluation Criteria In Solid Tumors (RECIST) guidelines or Choi criteria. Both require a period of time on therapy before changes indicative of response can be observed. In addition, neither informs directly about cell death. We evaluated the use of molecular imaging technology in an animal model using near-infrared (NIR) imaging probes together with three-dimensional fluorescence molecular tomography (FMT) for assessing therapeutic response and ultimately optimizing our understanding of the biologic effects of these agents. We determined the potential of NIR probes (PSVue(TM) 794 and cell-penetrating KcapQ647) for detecting distinct markers of apoptosis and compare this to tumor size measured by MRI in response to IM treatment in GIST-T1 xenografts. Our studies revealed statistically significant increases in apoptosis due to IM treatment using both probes as early as 24 h post IM treatment which was confirmed by IHC. Molecular imaging will allow for faster and more effective screening of novel therapies in preclinical GIST models." @default.
• W2000690501 created "2016-06-24" @default.
• W2000690501 creator A5028466230 @default.
• W2000690501 creator A5031081545 @default.
• W2000690501 creator A5033625395 @default.
• W2000690501 creator A5043865470 @default.
• W2000690501 creator A5051752608 @default.
• W2000690501 creator A5085336500 @default.
• W2000690501 creator A5091383750 @default.
• W2000690501 date "2014-04-22" @default.
• W2000690501 modified "2023-10-16" @default.
• W2000690501 title "Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging" @default.
• W2000690501 cites W1740757994 @default.
• W2000690501 cites W1980482008 @default.
• W2000690501 cites W1987857014 @default.
• W2000690501 cites W1998731934 @default.
• W2000690501 cites W2004477117 @default.
• W2000690501 cites W2035214704 @default.
• W2000690501 cites W2038677281 @default.
• W2000690501 cites W2053801110 @default.
• W2000690501 cites W2063956512 @default.
• W2000690501 cites W2067596492 @default.
• W2000690501 cites W2068079378 @default.
• W2000690501 cites W2087379950 @default.
• W2000690501 cites W2087567974 @default.
• W2000690501 cites W2101691808 @default.
• W2000690501 cites W2116922255 @default.
• W2000690501 cites W2121134942 @default.
• W2000690501 cites W2123534406 @default.
• W2000690501 cites W2125561235 @default.
• W2000690501 cites W2133407439 @default.
• W2000690501 cites W2139511378 @default.
• W2000690501 cites W2155652261 @default.
• W2000690501 doi "https://doi.org/10.4161/cbt.28880" @default.
• W2000690501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4100992" @default.
• W2000690501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24755645" @default.
• W2000690501 hasPublicationYear "2014" @default.
• W2000690501 type Work @default.
• W2000690501 sameAs 2000690501 @default.
• W2000690501 citedByCount "3" @default.
• W2000690501 countsByYear W20006905012015 @default.
• W2000690501 countsByYear W20006905012018 @default.
• W2000690501 crossrefType "journal-article" @default.
• W2000690501 hasAuthorship W2000690501A5028466230 @default.
• W2000690501 hasAuthorship W2000690501A5031081545 @default.
• W2000690501 hasAuthorship W2000690501A5033625395 @default.
• W2000690501 hasAuthorship W2000690501A5043865470 @default.
• W2000690501 hasAuthorship W2000690501A5051752608 @default.
• W2000690501 hasAuthorship W2000690501A5085336500 @default.
• W2000690501 hasAuthorship W2000690501A5091383750 @default.
• W2000690501 hasBestOaLocation W20006905011 @default.
• W2000690501 hasConcept C121608353 @default.
• W2000690501 hasConcept C126322002 @default.
• W2000690501 hasConcept C136339569 @default.
• W2000690501 hasConcept C142724271 @default.
• W2000690501 hasConcept C143998085 @default.
• W2000690501 hasConcept C150903083 @default.
• W2000690501 hasConcept C16930146 @default.
• W2000690501 hasConcept C190283241 @default.
• W2000690501 hasConcept C198826908 @default.
• W2000690501 hasConcept C207001950 @default.
• W2000690501 hasConcept C2775922572 @default.
• W2000690501 hasConcept C2777007597 @default.
• W2000690501 hasConcept C2777583451 @default.
• W2000690501 hasConcept C2778729363 @default.
• W2000690501 hasConcept C2778822529 @default.
• W2000690501 hasConcept C2779134260 @default.
• W2000690501 hasConcept C2779490328 @default.
• W2000690501 hasConcept C2779984678 @default.
• W2000690501 hasConcept C2781230642 @default.
• W2000690501 hasConcept C3019892230 @default.
• W2000690501 hasConcept C37307934 @default.
• W2000690501 hasConcept C502942594 @default.
• W2000690501 hasConcept C55493867 @default.
• W2000690501 hasConcept C71924100 @default.
• W2000690501 hasConcept C86803240 @default.
• W2000690501 hasConceptScore W2000690501C121608353 @default.
• W2000690501 hasConceptScore W2000690501C126322002 @default.
• W2000690501 hasConceptScore W2000690501C136339569 @default.
• W2000690501 hasConceptScore W2000690501C142724271 @default.
• W2000690501 hasConceptScore W2000690501C143998085 @default.
• W2000690501 hasConceptScore W2000690501C150903083 @default.
• W2000690501 hasConceptScore W2000690501C16930146 @default.
• W2000690501 hasConceptScore W2000690501C190283241 @default.
• W2000690501 hasConceptScore W2000690501C198826908 @default.
• W2000690501 hasConceptScore W2000690501C207001950 @default.
• W2000690501 hasConceptScore W2000690501C2775922572 @default.
• W2000690501 hasConceptScore W2000690501C2777007597 @default.
• W2000690501 hasConceptScore W2000690501C2777583451 @default.
• W2000690501 hasConceptScore W2000690501C2778729363 @default.
• W2000690501 hasConceptScore W2000690501C2778822529 @default.
• W2000690501 hasConceptScore W2000690501C2779134260 @default.
• W2000690501 hasConceptScore W2000690501C2779490328 @default.
• W2000690501 hasConceptScore W2000690501C2779984678 @default.
• W2000690501 hasConceptScore W2000690501C2781230642 @default.
• W2000690501 hasConceptScore W2000690501C3019892230 @default.
• W2000690501 hasConceptScore W2000690501C37307934 @default.
• W2000690501 hasConceptScore W2000690501C502942594 @default.

• next