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- W2000690983 endingPage "481" @default.
- W2000690983 startingPage "471" @default.
- W2000690983 abstract "This review considers the roles of transforming growth factor-β (TGF-β), the signaling Smad proteins, and angiotensin II (AT II) in conditions leading to human fibrosis. The goal is to update the burn practitioner and researcher about this important pathway and to introduce AT II as a possible synergistic signal to TGF-β in burn scarring. Literature searches of the MEDLINE database were performed for English manuscripts combinations of TGF-β, Smad, angiotensin, fibrosis, burn, and scar. AT II and TGF-β both activate the Smad protein system, which leads to the expression of genes related to fibrosis. In fibrotic conditions, such as tubulointerstitial nephritis, systemic sclerosis, and myocardial infarctions, AT II acts both independently and synergistically with TGF-β. Both AT II and TGF-β act through a messenger system, the Smad proteins that lead to excessive extracellular matrix formation. Treatment and research implications are reviewed. The interaction between AT II and TGF-β leading to fibrosis is well described in some human diseases. This pathway may be of importance in human burn scarring as well." @default.
- W2000690983 created "2016-06-24" @default.
- W2000690983 creator A5042994637 @default.
- W2000690983 date "2009-05-01" @default.
- W2000690983 modified "2023-10-14" @default.
- W2000690983 title "Transforming Growth Factor-β and Angiotensin in Fibrosis and Burn Injuries" @default.
- W2000690983 cites W1575754639 @default.
- W2000690983 cites W1905104097 @default.
- W2000690983 cites W1965464161 @default.
- W2000690983 cites W1966637341 @default.
- W2000690983 cites W1967775253 @default.
- W2000690983 cites W1970564104 @default.
- W2000690983 cites W1975158646 @default.
- W2000690983 cites W1976323674 @default.
- W2000690983 cites W1976618221 @default.
- W2000690983 cites W1977550083 @default.
- W2000690983 cites W1978822559 @default.
- W2000690983 cites W1979840934 @default.
- W2000690983 cites W1980063857 @default.
- W2000690983 cites W1983824614 @default.
- W2000690983 cites W1984449375 @default.
- W2000690983 cites W1984595187 @default.
- W2000690983 cites W1988270813 @default.
- W2000690983 cites W1989386822 @default.
- W2000690983 cites W1989410388 @default.
- W2000690983 cites W1990224341 @default.
- W2000690983 cites W1992213652 @default.
- W2000690983 cites W1994114299 @default.
- W2000690983 cites W1994812539 @default.
- W2000690983 cites W1995158939 @default.
- W2000690983 cites W1997269917 @default.
- W2000690983 cites W2001466282 @default.
- W2000690983 cites W2007180721 @default.
- W2000690983 cites W2009812326 @default.
- W2000690983 cites W2010677564 @default.
- W2000690983 cites W2012589561 @default.
- W2000690983 cites W2022196088 @default.
- W2000690983 cites W2025086989 @default.
- W2000690983 cites W2025581043 @default.
- W2000690983 cites W2025915995 @default.
- W2000690983 cites W2028929373 @default.
- W2000690983 cites W2031777569 @default.
- W2000690983 cites W2036116757 @default.
- W2000690983 cites W2036487040 @default.
- W2000690983 cites W2038329905 @default.
- W2000690983 cites W2039133374 @default.
- W2000690983 cites W2042644899 @default.
- W2000690983 cites W2045675607 @default.
- W2000690983 cites W2047543126 @default.
- W2000690983 cites W2049262181 @default.
- W2000690983 cites W2049602205 @default.
- W2000690983 cites W2052037115 @default.
- W2000690983 cites W2054108038 @default.
- W2000690983 cites W2055394339 @default.
- W2000690983 cites W2059289499 @default.
- W2000690983 cites W2062801814 @default.
- W2000690983 cites W2063247432 @default.
- W2000690983 cites W2065122137 @default.
- W2000690983 cites W2065476565 @default.
- W2000690983 cites W2065633653 @default.
- W2000690983 cites W2066879441 @default.
- W2000690983 cites W2069731288 @default.
- W2000690983 cites W2069912425 @default.
- W2000690983 cites W2070158632 @default.
- W2000690983 cites W2070192533 @default.
- W2000690983 cites W2071499127 @default.
- W2000690983 cites W2074325741 @default.
- W2000690983 cites W2077388392 @default.
- W2000690983 cites W2081195991 @default.
- W2000690983 cites W2085225963 @default.
- W2000690983 cites W2085960705 @default.
- W2000690983 cites W2087359567 @default.
- W2000690983 cites W2090969152 @default.
- W2000690983 cites W2091094644 @default.
- W2000690983 cites W2091582008 @default.
- W2000690983 cites W2092388342 @default.
- W2000690983 cites W2093301599 @default.
- W2000690983 cites W2094848681 @default.
- W2000690983 cites W2095025343 @default.
- W2000690983 cites W2095605427 @default.
- W2000690983 cites W2095946347 @default.
- W2000690983 cites W2099737510 @default.
- W2000690983 cites W2100570941 @default.
- W2000690983 cites W2100824125 @default.
- W2000690983 cites W2102516230 @default.
- W2000690983 cites W2102784194 @default.
- W2000690983 cites W2103430951 @default.
- W2000690983 cites W2107128634 @default.
- W2000690983 cites W2108448007 @default.
- W2000690983 cites W2120577501 @default.
- W2000690983 cites W2120707690 @default.
- W2000690983 cites W2122808924 @default.
- W2000690983 cites W2124006473 @default.
- W2000690983 cites W2125757459 @default.
- W2000690983 cites W2128931073 @default.
- W2000690983 cites W2147758809 @default.
- W2000690983 cites W2151350350 @default.
- W2000690983 cites W2153084809 @default.