FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000691496> ?p ?o ?g. }

• W2000691496 endingPage "677" @default.
• W2000691496 startingPage "668" @default.
• W2000691496 abstract "Background: Axon pruning is involved in establishment and maintenance of functional neural circuits. During metamorphosis of Drosophila, selective pruning of larval axons is developmentally regulated by ecdysone and caused by local axon degeneration. Previous studies have revealed intrinsic molecular and cellular mechanisms that trigger this pruning process, but how pruning is accomplished remains essentially unknown.Results: Detailed analysis of morphological changes in the axon branches of Drosophila mushroom body (MB) neurons revealed that during early pupal stages, clusters of neighboring varicosities, each of which belongs to different axons, disappear simultaneously shortly before the onset of local axon degeneration. At this stage, bundles of axon branches are infiltrated by the processes of surrounding glia. These processes engulf clusters of varicosities and accumulate intracellular degradative compartments. Selective inhibition of cellular functions, including endocytosis, in glial cells via the temperature-sensitive allele of shibire both suppresses glial infiltration and varicosity elimination and induces a severe delay in axon pruning. Selective inhibition of ecdysone receptors in the MB neurons severely suppressed not only axon pruning but also the infiltration and engulfing action of the surrounding glia.Conclusions: These findings strongly suggest that glial cells are extrinsically activated by ecdysone-stimulated MB neurons. These glial cells infiltrate the mass of axon branches to eliminate varicosities and break down axon branches actively rather than just scavenging already-degraded debris. We therefore propose that neuron-glia interaction is essential for the precisely coordinated axon-pruning process during Drosophila metamorphosis." @default.
• W2000691496 created "2016-06-24" @default.
• W2000691496 creator A5013738307 @default.
• W2000691496 creator A5045205154 @default.
• W2000691496 date "2004-04-01" @default.
• W2000691496 modified "2023-10-12" @default.
• W2000691496 title "Engulfing Action of Glial Cells Is Required for Programmed Axon Pruning during Drosophila Metamorphosis" @default.
• W2000691496 cites W1600079321 @default.
• W2000691496 cites W1782545213 @default.
• W2000691496 cites W1964996503 @default.
• W2000691496 cites W1967534538 @default.
• W2000691496 cites W1971200109 @default.
• W2000691496 cites W1973535514 @default.
• W2000691496 cites W1975055665 @default.
• W2000691496 cites W1975145685 @default.
• W2000691496 cites W1979799439 @default.
• W2000691496 cites W1980362465 @default.
• W2000691496 cites W1983216109 @default.
• W2000691496 cites W1984234078 @default.
• W2000691496 cites W1986552075 @default.
• W2000691496 cites W1988519721 @default.
• W2000691496 cites W1998105194 @default.
• W2000691496 cites W2006229889 @default.
• W2000691496 cites W2008450208 @default.
• W2000691496 cites W2009018171 @default.
• W2000691496 cites W2023218866 @default.
• W2000691496 cites W2027215260 @default.
• W2000691496 cites W2048743675 @default.
• W2000691496 cites W2065226275 @default.
• W2000691496 cites W2073133778 @default.
• W2000691496 cites W2080464961 @default.
• W2000691496 cites W2086075096 @default.
• W2000691496 cites W2087057470 @default.
• W2000691496 cites W2096059852 @default.
• W2000691496 cites W2104845360 @default.
• W2000691496 cites W2112943515 @default.
• W2000691496 cites W2133337732 @default.
• W2000691496 cites W2146291151 @default.
• W2000691496 cites W2151381548 @default.
• W2000691496 cites W2152437336 @default.
• W2000691496 cites W2155720250 @default.
• W2000691496 cites W2159330173 @default.
• W2000691496 cites W2161759578 @default.
• W2000691496 cites W2162207411 @default.
• W2000691496 cites W2168964226 @default.
• W2000691496 doi "https://doi.org/10.1016/j.cub.2004.04.001" @default.
• W2000691496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15084281" @default.
• W2000691496 hasPublicationYear "2004" @default.
• W2000691496 type Work @default.
• W2000691496 sameAs 2000691496 @default.
• W2000691496 citedByCount "198" @default.
• W2000691496 countsByYear W20006914962012 @default.
• W2000691496 countsByYear W20006914962013 @default.
• W2000691496 countsByYear W20006914962014 @default.
• W2000691496 countsByYear W20006914962015 @default.
• W2000691496 countsByYear W20006914962016 @default.
• W2000691496 countsByYear W20006914962017 @default.
• W2000691496 countsByYear W20006914962018 @default.
• W2000691496 countsByYear W20006914962019 @default.
• W2000691496 countsByYear W20006914962020 @default.
• W2000691496 countsByYear W20006914962021 @default.
• W2000691496 countsByYear W20006914962022 @default.
• W2000691496 countsByYear W20006914962023 @default.
• W2000691496 crossrefType "journal-article" @default.
• W2000691496 hasAuthorship W2000691496A5013738307 @default.
• W2000691496 hasAuthorship W2000691496A5045205154 @default.
• W2000691496 hasBestOaLocation W20006914961 @default.
• W2000691496 hasConcept C104317684 @default.
• W2000691496 hasConcept C136397037 @default.
• W2000691496 hasConcept C16744765 @default.
• W2000691496 hasConcept C169760540 @default.
• W2000691496 hasConcept C173758957 @default.
• W2000691496 hasConcept C2776038537 @default.
• W2000691496 hasConcept C2777180181 @default.
• W2000691496 hasConcept C2778794669 @default.
• W2000691496 hasConcept C2779530196 @default.
• W2000691496 hasConcept C2779617337 @default.
• W2000691496 hasConcept C2780104201 @default.
• W2000691496 hasConcept C54355233 @default.
• W2000691496 hasConcept C59822182 @default.
• W2000691496 hasConcept C86803240 @default.
• W2000691496 hasConcept C95444343 @default.
• W2000691496 hasConceptScore W2000691496C104317684 @default.
• W2000691496 hasConceptScore W2000691496C136397037 @default.
• W2000691496 hasConceptScore W2000691496C16744765 @default.
• W2000691496 hasConceptScore W2000691496C169760540 @default.
• W2000691496 hasConceptScore W2000691496C173758957 @default.
• W2000691496 hasConceptScore W2000691496C2776038537 @default.
• W2000691496 hasConceptScore W2000691496C2777180181 @default.
• W2000691496 hasConceptScore W2000691496C2778794669 @default.
• W2000691496 hasConceptScore W2000691496C2779530196 @default.
• W2000691496 hasConceptScore W2000691496C2779617337 @default.
• W2000691496 hasConceptScore W2000691496C2780104201 @default.
• W2000691496 hasConceptScore W2000691496C54355233 @default.
• W2000691496 hasConceptScore W2000691496C59822182 @default.
• W2000691496 hasConceptScore W2000691496C86803240 @default.
• W2000691496 hasConceptScore W2000691496C95444343 @default.
• W2000691496 hasIssue "8" @default.

• next