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- W2000692415 abstract "Although depressive symptoms (DEP) are common in hospitalized elders, it is not known whether they predict long-term mortality independently of other prognostic factors. Therefore, the authors determined the relationship between DEP on admission (ADM) and 3-year mortality in 572 hospitalized general medical patients (mean age=80, 68% women). The authors measured DEP using the 15-item geriatric depression scale, and patients were divided into tertiles: 0–2 DEP (n=181), 3–5 DEP (n=195), and 6–15 DEP (n=196). The authors also measured illness severity (APACHE II scores), comorbidity (Charlson scores), physical function (nurse assessed dependence in 6 ADLs), and cognitive function (MMSE) on admission. Patients with ≥6 DEP on ADM had a higher 3-year mortality rates than patients with 3–5 or 0–2 DEP (56% vs. 42% vs. 39%, respectively, P<0.01). On ADM, patients with ≥6 DEP had higher Charlson scores (P<0.01) and were dependent in more ADL (P<0.01) than patients with fewer DEP. Table 1 shows hazard ratios for mortality over 3 years in each of the tertiles for 2 successive Cox regression models: Model 1, adjusting for age, race, and gender; Model 2 adjusting for age, race, gender, illness severity, comorbidity, physical function, and cognitive function. The authors conclude that the relationship between DEP and 3-year mortality is partially explained by greater illness severity and functional impairment in patients with more DEP. Nonetheless, after adjustment for these factors, ≥6 DEP remained independently associated with 3-year mortality in hospitalized elders. P67 TABLE 1Hazard ratios for mortality over 3 years for two Cox regression models DEP Model 1 Model 2 Tertile Hazard Ratio/95% CI 0–2 1.0 1.0 3–5 1.1 (0.8–1.5) 1.0 (0.7–1.4) ≥ 6 1.7 (1.3–2.3) 1.4 (1.0–1.9) Open table in a new tab" @default.
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- W2000692415 date "1999-09-01" @default.
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- W2000692415 title "DEPRESSIVE SYMPTOMS AND THREE-YEAR MORTALITY IN HOSPITALIZED ELDERS" @default.
- W2000692415 doi "https://doi.org/10.1097/00019442-199911001-00120" @default.
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