Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000693050> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2000693050 endingPage "287" @default.
- W2000693050 startingPage "282" @default.
- W2000693050 abstract "Plaque purification of the M variant of encephalomyocarditis (EMC-M) virus resulted in the isolation of two stable variants. One is a highly diabetogenic D variant (EMC-D) and the other is a nondiabetogenic B variant (EMC-B). The cDNA of EMC-D and EMC-B genomes were cloned and seven overlapping cDNA clones were selected to cover the entire genome except the 5'-end 310 bases which were determined by RNA-dependent DNA sequencing and enzymatic RNA sequencing. Each clone was restriction-mapped, subcloned, and sequenced. The genomes of EMC-D and EMC-B are composed of 7829 and 7825 bases, respectively. Both genomes contain a long open reading frame of 6876 nucleotides starting at position 830 on the consensus sequence, which encodes a polyprotein of 2292 amino acids. The sequences of EMC-D and EMC-B differ by two deletions, one insertion, and eight point mutations. The first deletion of 3 nucleotides is located in the 5' poly(C) tract where EMC-B has 127 nucleotides compared with 130 nucleotides in EMC-D. The second deletion in EMC-B involves 2 nucleotides at the 3'-end polyadenylation site. A single base insertion of U occurs at the 5' noncoding region of EMC-B. The eight point mutations are located in the polyprotein coding region. Two are silent and are each located in the structural gene 1B and in the nonstructural gene 2B. The remaining six mutations, one on the L gene and the other five on the 1D gene, introduce respective amino acid changes. It is concluded that the diabetogenic EMC-D viral genome (7829 bases) differs from the nondiabetogenic EMC-B viral genome (7825 bases) by 14 nucleotides out of 7829." @default.
- W2000693050 created "2016-06-24" @default.
- W2000693050 creator A5023815958 @default.
- W2000693050 creator A5031820564 @default.
- W2000693050 creator A5044000185 @default.
- W2000693050 date "1989-05-01" @default.
- W2000693050 modified "2023-10-14" @default.
- W2000693050 title "Genomic differences between the diabetogenic and nondiabetogenic variants of encephalomyocarditis virus" @default.
- W2000693050 cites W1493610845 @default.
- W2000693050 cites W1642888116 @default.
- W2000693050 cites W1812098892 @default.
- W2000693050 cites W1937264098 @default.
- W2000693050 cites W1975304761 @default.
- W2000693050 cites W1983284057 @default.
- W2000693050 cites W2002075344 @default.
- W2000693050 cites W2004228512 @default.
- W2000693050 cites W2019261730 @default.
- W2000693050 cites W2022852102 @default.
- W2000693050 cites W2037263249 @default.
- W2000693050 cites W2040738644 @default.
- W2000693050 cites W2051084191 @default.
- W2000693050 cites W2054468433 @default.
- W2000693050 cites W2060520834 @default.
- W2000693050 cites W2086937185 @default.
- W2000693050 cites W2089238196 @default.
- W2000693050 cites W2090608105 @default.
- W2000693050 cites W2117073405 @default.
- W2000693050 cites W2118814568 @default.
- W2000693050 cites W2151984697 @default.
- W2000693050 cites W2157092967 @default.
- W2000693050 doi "https://doi.org/10.1016/0042-6822(89)90379-6" @default.
- W2000693050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2541543" @default.
- W2000693050 hasPublicationYear "1989" @default.
- W2000693050 type Work @default.
- W2000693050 sameAs 2000693050 @default.
- W2000693050 citedByCount "70" @default.
- W2000693050 countsByYear W20006930502012 @default.
- W2000693050 countsByYear W20006930502013 @default.
- W2000693050 countsByYear W20006930502015 @default.
- W2000693050 countsByYear W20006930502019 @default.
- W2000693050 countsByYear W20006930502020 @default.
- W2000693050 crossrefType "journal-article" @default.
- W2000693050 hasAuthorship W2000693050A5023815958 @default.
- W2000693050 hasAuthorship W2000693050A5031820564 @default.
- W2000693050 hasAuthorship W2000693050A5044000185 @default.
- W2000693050 hasConcept C104317684 @default.
- W2000693050 hasConcept C141231307 @default.
- W2000693050 hasConcept C153911025 @default.
- W2000693050 hasConcept C176944494 @default.
- W2000693050 hasConcept C187882448 @default.
- W2000693050 hasConcept C501734568 @default.
- W2000693050 hasConcept C54355233 @default.
- W2000693050 hasConcept C67705224 @default.
- W2000693050 hasConcept C84148353 @default.
- W2000693050 hasConcept C86803240 @default.
- W2000693050 hasConceptScore W2000693050C104317684 @default.
- W2000693050 hasConceptScore W2000693050C141231307 @default.
- W2000693050 hasConceptScore W2000693050C153911025 @default.
- W2000693050 hasConceptScore W2000693050C176944494 @default.
- W2000693050 hasConceptScore W2000693050C187882448 @default.
- W2000693050 hasConceptScore W2000693050C501734568 @default.
- W2000693050 hasConceptScore W2000693050C54355233 @default.
- W2000693050 hasConceptScore W2000693050C67705224 @default.
- W2000693050 hasConceptScore W2000693050C84148353 @default.
- W2000693050 hasConceptScore W2000693050C86803240 @default.
- W2000693050 hasIssue "1" @default.
- W2000693050 hasLocation W20006930501 @default.
- W2000693050 hasLocation W20006930502 @default.
- W2000693050 hasOpenAccess W2000693050 @default.
- W2000693050 hasPrimaryLocation W20006930501 @default.
- W2000693050 hasRelatedWork W1982291777 @default.
- W2000693050 hasRelatedWork W1989391836 @default.
- W2000693050 hasRelatedWork W2028961943 @default.
- W2000693050 hasRelatedWork W2031846255 @default.
- W2000693050 hasRelatedWork W2042379947 @default.
- W2000693050 hasRelatedWork W2069184423 @default.
- W2000693050 hasRelatedWork W2121437105 @default.
- W2000693050 hasRelatedWork W2391633642 @default.
- W2000693050 hasRelatedWork W2173258789 @default.
- W2000693050 hasRelatedWork W2187207551 @default.
- W2000693050 hasVolume "170" @default.
- W2000693050 isParatext "false" @default.
- W2000693050 isRetracted "false" @default.
- W2000693050 magId "2000693050" @default.
- W2000693050 workType "article" @default.