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- W2000693133 abstract "B cells are critical players in the orchestration of properly regulated immune responses, providing protection against infectious agents without inflicting autoinflammatory damage. A balanced B cell compartment is also essential to create protective immunity in response to vaccines. This difficult compromise is achieved through the finely regulated participation of multiple B cell populations with different antibody-dependent and independent functions. Both types of functions allow B cells to powerfully modulate other components of the innate and adaptive immune system. For the most part, however, the necessary division of labor among different B cell populations is poorly understood. B cell dysfunction has been implicated in multiple autoimmune conditions. The physiological importance and complexity of B cell functions has been brought to the fore in recent years by the success of rituximab-based B cell depletion therapy (BCDT) in multiple autoimmune diseases including rheumatoid arthritis (RA) and multiple sclerosis (MS) which are conventionally viewed as T-cell mediated conditions. Given the widespread utilization of BCDT in malignant and autoimmune diseases and the key role of B cells in both protective immunity and pathogenic autoimmunity, a better understanding of B cell functions is of the essence and a focus of the research in our division. We are investigating these issues through a variety of approaches, including the study of the phenotype and function of human B cell populations in health, their perturbation in autoimmune disease states, the effects of targeted biologic therapies, and the study of relevant murine models." @default.
- W2000693133 created "2016-06-24" @default.
- W2000693133 creator A5000051455 @default.
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- W2000693133 date "2009-04-07" @default.
- W2000693133 modified "2023-09-23" @default.
- W2000693133 title "Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets" @default.
- W2000693133 cites W1480160648 @default.
- W2000693133 cites W1489377722 @default.
- W2000693133 cites W1504970236 @default.
- W2000693133 cites W1521119381 @default.
- W2000693133 cites W1541663213 @default.
- W2000693133 cites W1547450219 @default.
- W2000693133 cites W159968576 @default.
- W2000693133 cites W1642392901 @default.
- W2000693133 cites W1785971308 @default.
- W2000693133 cites W1847270645 @default.
- W2000693133 cites W1852406183 @default.
- W2000693133 cites W1910692743 @default.
- W2000693133 cites W1918941126 @default.
- W2000693133 cites W1930962503 @default.
- W2000693133 cites W1935239049 @default.
- W2000693133 cites W1935840505 @default.
- W2000693133 cites W1946226823 @default.
- W2000693133 cites W1964453920 @default.
- W2000693133 cites W1967051290 @default.
- W2000693133 cites W1967380173 @default.
- W2000693133 cites W1970742017 @default.
- W2000693133 cites W1971286997 @default.
- W2000693133 cites W1971290104 @default.
- W2000693133 cites W1973431560 @default.
- W2000693133 cites W1974369659 @default.
- W2000693133 cites W1975300245 @default.
- W2000693133 cites W1982094117 @default.
- W2000693133 cites W1997452174 @default.
- W2000693133 cites W1997826759 @default.
- W2000693133 cites W1998618256 @default.
- W2000693133 cites W2001710332 @default.
- W2000693133 cites W2002073873 @default.
- W2000693133 cites W2004111877 @default.
- W2000693133 cites W2009074857 @default.
- W2000693133 cites W2011644457 @default.
- W2000693133 cites W2015564999 @default.
- W2000693133 cites W2015817628 @default.
- W2000693133 cites W2015945927 @default.
- W2000693133 cites W2017905451 @default.
- W2000693133 cites W2020937131 @default.
- W2000693133 cites W2024235155 @default.
- W2000693133 cites W2028234551 @default.
- W2000693133 cites W2031302274 @default.
- W2000693133 cites W2031321129 @default.
- W2000693133 cites W2031503850 @default.
- W2000693133 cites W2038783844 @default.
- W2000693133 cites W2040876247 @default.
- W2000693133 cites W2046637170 @default.
- W2000693133 cites W2048283731 @default.
- W2000693133 cites W2053669192 @default.
- W2000693133 cites W2060407329 @default.
- W2000693133 cites W2063150581 @default.
- W2000693133 cites W2063212054 @default.
- W2000693133 cites W2067977374 @default.
- W2000693133 cites W2068318977 @default.
- W2000693133 cites W2071330332 @default.
- W2000693133 cites W2075067819 @default.
- W2000693133 cites W2076971074 @default.
- W2000693133 cites W2077297620 @default.
- W2000693133 cites W2077570217 @default.
- W2000693133 cites W2080773387 @default.
- W2000693133 cites W2083141507 @default.
- W2000693133 cites W2084547554 @default.
- W2000693133 cites W2085062445 @default.
- W2000693133 cites W2085425007 @default.
- W2000693133 cites W2085465802 @default.
- W2000693133 cites W2089016290 @default.
- W2000693133 cites W2089314795 @default.
- W2000693133 cites W2093761064 @default.
- W2000693133 cites W2094990294 @default.
- W2000693133 cites W2099868898 @default.
- W2000693133 cites W2101727960 @default.
- W2000693133 cites W2104492395 @default.
- W2000693133 cites W2106471879 @default.
- W2000693133 cites W2107455390 @default.
- W2000693133 cites W2109553594 @default.
- W2000693133 cites W2110882920 @default.
- W2000693133 cites W2117935973 @default.
- W2000693133 cites W2118994799 @default.
- W2000693133 cites W2126746651 @default.
- W2000693133 cites W2129806278 @default.
- W2000693133 cites W2131991510 @default.
- W2000693133 cites W2134547857 @default.
- W2000693133 cites W2135943092 @default.
- W2000693133 cites W2137703086 @default.
- W2000693133 cites W2141111992 @default.
- W2000693133 cites W2143460407 @default.
- W2000693133 cites W2146764660 @default.