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• W2000693477 abstract "A novel class of selective inhibitors of ROCK1 and ROCK2 has been identified by structural based drug design. PK/PD experiments using a set of highly selective Rho kinase inhibitors suggest that systemic Rho kinase inhibition is linked to a reversible reduction in lymphocyte counts. These results led to the consideration of topical delivery of these molecules, and to the identification of a lead molecule 7 which shows promising PK and PD in a murine model of pulmonary hypertension after intra-tracheal dosing." @default.
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• W2000693477 date "2014-10-01" @default.
• W2000693477 modified "2023-09-30" @default.
• W2000693477 title "Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension" @default.
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• W2000693477 doi "https://doi.org/10.1016/j.bmcl.2014.09.002" @default.
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