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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000693909> ?p ?o ?g. }

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• W2000693909 abstract "Lysophosphatidylcholine (lyso-PC) selectively upregulates the mRNA level of intercellular adhesion molecule-1 (ICAM-1) but not that of vascular cell adhesion molecule-1 (VCAM-1) in cultured human umbilical vein endothelial cells. Transfection studies show that lyso-PC activates the ICAM-1 promoter but not the VCAM-1 promoter. Gel mobility shift assays document an increase in NF-κB binding in cells treated with lyso-PC. The increases of ICAM-1 mRNA and NF-κB binding were inhibited by the protein tyrosine kinase inhibitors, genistein and lavendustin A, but not by inhibitors for cyclic AMP-dependent protein kinases or protein kinase C. Our results suggest that lyso-PC induces ICAM-1 expression most likely by activating NF-κB, and that the effect appears to be protein tyrosine kinase-dependent." @default.
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• W2000693909 date "1997-03-01" @default.
• W2000693909 modified "2023-10-16" @default.
• W2000693909 title "Activation of ICAM-1 promoter by lysophosphatidylcholine: Possible involvement of protein tyrosine kinases" @default.
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• W2000693909 doi "https://doi.org/10.1016/s0005-2760(96)00169-5" @default.
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