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• W2000694690 abstract "Background: Traumatic brain injury (TBI) causes gastrointestinal dysfunction and increased intestinal permeability. Regulation of the gut barrier may involve the central nervous system. We hypothesize that vagal nerve stimulation prevents an increase in intestinal permeability after TBI. Methods: Balb/c mice underwent a weight drop TBI. Selected mice had electrical stimulation of the cervical vagus nerve before TBI. Intestinal permeability to 4.4 kDa FITC-Dextran was measured 6 hours after injury. Ileum was harvested and intestinal tumor necrosis factor-α and glial fibrillary acidic protein (GFAP), a marker of glial activity, were measured. Results: TBI increased intestinal permeability compared with sham, 6 hours after injury (98.5 μg/mL ± 12.5 vs. 29.5 μg/mL ± 5.9 μg/mL; p < 0.01). Vagal stimulation prevented TBI-induced intestinal permeability (55.8 ± 4.8 μg/mL vs. 98.49 μg/mL ± 12.5; p < 0.02). TBI animals had an increase in intestinal tumor necrosis factor-α 6 hours after injury compared with vagal stimulation + TBI (45.6 ± 8.6 pg/mL vs. 24.1 ± 1.4 pg/mL; p < 0.001). TBI increased intestinal GFAP 6.2-fold higher than sham at 2 hours and 11.5-fold higher at 4 hours after injury (p < 0.05). Intestinal GFAP in vagal stimulation + TBI animals was also 6.7-fold higher than sham at 2 hours, however, intestinal GFAP was 18.0-fold higher at 4 hours compared with sham and 1.6-fold higher than TBI alone (p < 0.05). Conclusion: In a mouse model of TBI, vagal stimulation prevented TBI-induced intestinal permeability. Furthermore, vagal stimulation increased enteric glial activity and may represent the pathway for central nervous system regulation of intestinal permeability." @default.
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• W2000694690 date "2010-05-01" @default.
• W2000694690 modified "2023-10-15" @default.
• W2000694690 title "Stimulating the Central Nervous System to Prevent Intestinal Dysfunction After Traumatic Brain Injury" @default.
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• W2000694690 doi "https://doi.org/10.1097/ta.0b013e3181d87373" @default.
• W2000694690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4251579" @default.
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