FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000694785> ?p ?o ?g. }

• W2000694785 endingPage "233" @default.
• W2000694785 startingPage "221" @default.
• W2000694785 abstract "Microsomal P450-mediated monooxygenase activity supported by NADPH requires an interaction between flavoprotein NADPH-cytochrome P450 reductase and cytochrome P450. These proteins have been identified as the simplest system (with the inclusion of a phospholipid (PL) component) that possesses monooxygenase function; however, little is known about the organization of these proteins in the microsomal membrane. Although reductase and P450 are known to form a 1:1 functional complex, there exists a 10- to 20-fold excess of P450 over the reductase. This raises several questions including How are the enzymes of the P450 system organized in the microsomal membrane? and Can one P450 enzyme affect the functional characteristics of another P450? This review summarizes evidence supporting the potential for enzymes involved in the P450 system to interact, focusing on the interactions between reductase and P450 and interactions between multiple P450 enzymes. Studies on the aggregation characteristics of P450 as well as on rotational diffusion are detailed, with a special emphasis on the potential for P450 enzymes to produce oligomeric complexes and to suggest the environment in which P450 exists in the endoplasmic reticulum. Finally, more recent studies describing the potential for multiple P450s to exist as complexes and their effect on P450 function are presented, including studies using reconstituted systems as well as systems where two P450s are coexpressed in the presence of reductase. An understanding of the interactions among reductase and multiple P450s is important for predicting conditions where the drug disposition may be altered by the direct effects of P450-P450 complex formation. Furthermore, the potential for one P450 enzyme to affect the behavior of another P450 may be extremely important for drug screening and development, requiring metabolic screening of a drug with reconstituted systems containing multiple P450s rather than simpler systems containing only a single form." @default.
• W2000694785 created "2016-06-24" @default.
• W2000694785 creator A5051060653 @default.
• W2000694785 creator A5076647370 @default.
• W2000694785 date "2003-05-01" @default.
• W2000694785 modified "2023-09-29" @default.
• W2000694785 title "Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes" @default.
• W2000694785 cites W1229227566 @default.
• W2000694785 cites W1234052980 @default.
• W2000694785 cites W1247495390 @default.
• W2000694785 cites W1480425469 @default.
• W2000694785 cites W1488793801 @default.
• W2000694785 cites W1504804986 @default.
• W2000694785 cites W1509553808 @default.
• W2000694785 cites W1515458478 @default.
• W2000694785 cites W1527380199 @default.
• W2000694785 cites W1530602575 @default.
• W2000694785 cites W1546744738 @default.
• W2000694785 cites W1551046532 @default.
• W2000694785 cites W1553094910 @default.
• W2000694785 cites W1553966958 @default.
• W2000694785 cites W1566398256 @default.
• W2000694785 cites W1572519525 @default.
• W2000694785 cites W1588794217 @default.
• W2000694785 cites W1590455940 @default.
• W2000694785 cites W1593473776 @default.
• W2000694785 cites W1595414536 @default.
• W2000694785 cites W1597150712 @default.
• W2000694785 cites W1603947018 @default.
• W2000694785 cites W1700470441 @default.
• W2000694785 cites W1864416475 @default.
• W2000694785 cites W1967636653 @default.
• W2000694785 cites W1967752483 @default.
• W2000694785 cites W1967972840 @default.
• W2000694785 cites W1968129594 @default.
• W2000694785 cites W1985925852 @default.
• W2000694785 cites W1989590944 @default.
• W2000694785 cites W1990236572 @default.
• W2000694785 cites W1991058493 @default.
• W2000694785 cites W1992119540 @default.
• W2000694785 cites W2004208423 @default.
• W2000694785 cites W2006465601 @default.
• W2000694785 cites W2006998778 @default.
• W2000694785 cites W2013847444 @default.
• W2000694785 cites W2016506624 @default.
• W2000694785 cites W2023547733 @default.
• W2000694785 cites W2023951398 @default.
• W2000694785 cites W2027558365 @default.
• W2000694785 cites W2028161167 @default.
• W2000694785 cites W2034551014 @default.
• W2000694785 cites W2036859775 @default.
• W2000694785 cites W2037147213 @default.
• W2000694785 cites W2038244727 @default.
• W2000694785 cites W2043797143 @default.
• W2000694785 cites W2047362094 @default.
• W2000694785 cites W2048342700 @default.
• W2000694785 cites W2050246593 @default.
• W2000694785 cites W2054192469 @default.
• W2000694785 cites W2058264492 @default.
• W2000694785 cites W2060020241 @default.
• W2000694785 cites W2071758350 @default.
• W2000694785 cites W2074422478 @default.
• W2000694785 cites W2076943035 @default.
• W2000694785 cites W2082727101 @default.
• W2000694785 cites W2084161387 @default.
• W2000694785 cites W2086110770 @default.
• W2000694785 cites W2086941738 @default.
• W2000694785 cites W2095063364 @default.
• W2000694785 cites W2117917400 @default.
• W2000694785 cites W2126592776 @default.
• W2000694785 doi "https://doi.org/10.1016/s0163-7258(03)00031-7" @default.
• W2000694785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12725870" @default.
• W2000694785 hasPublicationYear "2003" @default.
• W2000694785 type Work @default.
• W2000694785 sameAs 2000694785 @default.
• W2000694785 citedByCount "135" @default.
• W2000694785 countsByYear W20006947852012 @default.
• W2000694785 countsByYear W20006947852013 @default.
• W2000694785 countsByYear W20006947852015 @default.
• W2000694785 countsByYear W20006947852016 @default.
• W2000694785 countsByYear W20006947852017 @default.
• W2000694785 countsByYear W20006947852018 @default.
• W2000694785 countsByYear W20006947852019 @default.
• W2000694785 countsByYear W20006947852020 @default.
• W2000694785 countsByYear W20006947852021 @default.
• W2000694785 countsByYear W20006947852022 @default.
• W2000694785 countsByYear W20006947852023 @default.
• W2000694785 crossrefType "journal-article" @default.
• W2000694785 hasAuthorship W2000694785A5051060653 @default.
• W2000694785 hasAuthorship W2000694785A5076647370 @default.
• W2000694785 hasConcept C13002179 @default.
• W2000694785 hasConcept C134651460 @default.
• W2000694785 hasConcept C14036430 @default.
• W2000694785 hasConcept C14471203 @default.
• W2000694785 hasConcept C158617107 @default.
• W2000694785 hasConcept C171305022 @default.
• W2000694785 hasConcept C181199279 @default.
• W2000694785 hasConcept C185592680 @default.

• next