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- W2000695783 endingPage "319" @default.
- W2000695783 startingPage "311" @default.
- W2000695783 abstract "A number of preclinical studies have shown the adeno-associated virus (AAV) to be an efficient vehicle for gene therapy. Clinical studies successfully demonstrated its potential for in vivo gene transfer. The complexity of host-vector interactions when progressing from small to large animal models, and eventually to humans, has impeded translation of AAV technology to the clinic. One approach to address this complexity has been to explore the biological characteristics of variations in AAV capsid structure. Initial strategies characterized the naturally occurring capsid variants from mammalian species. The structural and functional knowledge gathered on these natural AAV variants as vectors has led to the first series of second-generation vectors that aim at specifically improving certain properties by rational design of the capsid. A third exciting approach uses directed evolution to isolate vectors that are able to overcome selective pressures applied in the laboratory and thereby steer the capsid to evolve toward improved functionality." @default.
- W2000695783 created "2016-06-24" @default.
- W2000695783 creator A5009470292 @default.
- W2000695783 creator A5009839456 @default.
- W2000695783 creator A5051344823 @default.
- W2000695783 date "2008-12-04" @default.
- W2000695783 modified "2023-10-03" @default.
- W2000695783 title "Tailoring the AAV vector capsid for gene therapy" @default.
- W2000695783 cites W1487084354 @default.
- W2000695783 cites W1505196125 @default.
- W2000695783 cites W1598111769 @default.
- W2000695783 cites W1963623233 @default.
- W2000695783 cites W1965786463 @default.
- W2000695783 cites W1966493859 @default.
- W2000695783 cites W1968382713 @default.
- W2000695783 cites W1970138286 @default.
- W2000695783 cites W1971410862 @default.
- W2000695783 cites W1973658117 @default.
- W2000695783 cites W1975528602 @default.
- W2000695783 cites W1976329054 @default.
- W2000695783 cites W1977108718 @default.
- W2000695783 cites W1978519692 @default.
- W2000695783 cites W1982869964 @default.
- W2000695783 cites W1984764475 @default.
- W2000695783 cites W1987013465 @default.
- W2000695783 cites W1988197108 @default.
- W2000695783 cites W2000185853 @default.
- W2000695783 cites W2003523739 @default.
- W2000695783 cites W2007261697 @default.
- W2000695783 cites W2008254103 @default.
- W2000695783 cites W2008289270 @default.
- W2000695783 cites W2008389564 @default.
- W2000695783 cites W2008895870 @default.
- W2000695783 cites W2012104351 @default.
- W2000695783 cites W2014537162 @default.
- W2000695783 cites W2017608179 @default.
- W2000695783 cites W2019656743 @default.
- W2000695783 cites W2021202438 @default.
- W2000695783 cites W2022161423 @default.
- W2000695783 cites W2024617071 @default.
- W2000695783 cites W2025763389 @default.
- W2000695783 cites W2029612951 @default.
- W2000695783 cites W2031675363 @default.
- W2000695783 cites W2033689077 @default.
- W2000695783 cites W2036877355 @default.
- W2000695783 cites W2041157989 @default.
- W2000695783 cites W2042598793 @default.
- W2000695783 cites W2042811786 @default.
- W2000695783 cites W2045292147 @default.
- W2000695783 cites W2046488302 @default.
- W2000695783 cites W2046740401 @default.
- W2000695783 cites W2047608515 @default.
- W2000695783 cites W2047667011 @default.
- W2000695783 cites W2048008983 @default.
- W2000695783 cites W2053706844 @default.
- W2000695783 cites W2054677438 @default.
- W2000695783 cites W2057548071 @default.
- W2000695783 cites W2058010019 @default.
- W2000695783 cites W2062249345 @default.
- W2000695783 cites W2064199560 @default.
- W2000695783 cites W2065380345 @default.
- W2000695783 cites W2066015597 @default.
- W2000695783 cites W2068359087 @default.
- W2000695783 cites W2072311045 @default.
- W2000695783 cites W2077265814 @default.
- W2000695783 cites W2079248564 @default.
- W2000695783 cites W2080951809 @default.
- W2000695783 cites W2088555526 @default.
- W2000695783 cites W2090256568 @default.
- W2000695783 cites W2091134968 @default.
- W2000695783 cites W2091177028 @default.
- W2000695783 cites W2095401453 @default.
- W2000695783 cites W2097092564 @default.
- W2000695783 cites W2097281779 @default.
- W2000695783 cites W2098603564 @default.
- W2000695783 cites W2102111681 @default.
- W2000695783 cites W2103918419 @default.
- W2000695783 cites W2107753368 @default.
- W2000695783 cites W2109751467 @default.
- W2000695783 cites W2110746342 @default.
- W2000695783 cites W2111837903 @default.
- W2000695783 cites W2113082692 @default.
- W2000695783 cites W2113444875 @default.
- W2000695783 cites W2113637218 @default.
- W2000695783 cites W2120777256 @default.
- W2000695783 cites W2120913633 @default.
- W2000695783 cites W2125160350 @default.
- W2000695783 cites W2125375279 @default.
- W2000695783 cites W2128033750 @default.
- W2000695783 cites W2136085939 @default.
- W2000695783 cites W2136742761 @default.
- W2000695783 cites W2137222303 @default.
- W2000695783 cites W2137702198 @default.
- W2000695783 cites W2138104392 @default.
- W2000695783 cites W2141236766 @default.
- W2000695783 cites W2145365087 @default.
- W2000695783 cites W2147193337 @default.
- W2000695783 cites W2147844196 @default.