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- W2000696102 abstract "The development of a mouse model for poliomyelitis that is transgenic for the human poliovirus receptor (hPVR) has made it much easier to investigate the efficiency of the viral dissemination process in a whole organism. These studies have given an insight into the mechanisms of blood-brain barrier permeation and neural transport. Strain-specific neurovirulence levels, however, appear to depend mainly on the replicating capacity of the virus in the central nervous system rather than the dissemination efficiency. Studies of the poliovirus-induced cytopathic effects on neural cells and specific subcellular localization of hPVR isoforms might determine a new course of investigation of poliovirus pathogenesis." @default.
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- W2000696102 date "2001-10-01" @default.
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- W2000696102 title "Recent insights into poliovirus pathogenesis" @default.
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- W2000696102 doi "https://doi.org/10.1016/s0966-842x(01)02200-4" @default.
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