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- W2000696229 abstract "Mash1 is a transcription factor required during embryogenesis for the development of multiple neural lineages. It is expressed in restricted domains at specific stages in the developing central and peripheral nervous systems and in the developing olfactory epithelium. We have investigated the regulation ofMash1expression during embryogenesis using transgenic mice containingMash1/lacZreporter constructs.Cis-acting regulatory elements controllingMash1expression in the central nervous system are located within an 8-kb sequence upstream of theMash1coding region. This 8-kb sequence does not contain elements directing expression to the peripheral nervous system, olfactory epithelium, or retina. Sequences outside this 8 kb but within 36 kb of theMash1locus contain elements responsible for expression in the autonomic division of the peripheral nervous system. However, transgene expression in embryos containing the 36-kb sequence was never detected in the olfactory epithelium and retina. Thus, regulatory elements driving expression in these lineages may be at even greater distances from theMash1coding region. These data provide evidence for complex regulation ofMash1expression in which multiple lineage-specificcis-acting regulatory regions span greater than 36 kb of theMash1locus. Further characterization of these regions will facilitate the study of factors that regulate the temporal and spatial expression ofMash1during development. In addition, the regulatory sequences identified here can direct expression of heterologous genes to developing neural lineages that normally expressMash1,thus providing an important tool for examining the function of candidate regulatory genes in mammalian nervous system development." @default.
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- W2000696229 date "1996-12-01" @default.
- W2000696229 modified "2023-09-27" @default.
- W2000696229 title "Lineage-Specific Regulation of the Neural Differentiation GeneMASH1" @default.
- W2000696229 doi "https://doi.org/10.1006/dbio.1996.0332" @default.
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