Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000696560> ?p ?o ?g. }
- W2000696560 endingPage "339" @default.
- W2000696560 startingPage "330" @default.
- W2000696560 abstract "Effective treatments for patients suffering from chronic pain remain an area of intense focus within the pharmaceutical industry, as the development of novel therapies would help to treat an area of significant unmet medical need. The successful development of pharmacological agents to treat inflammatory and neuropathic pain conditions relies on a thorough understanding of the mechanisms that underlie the development and maintenance of chronic pain states. The goal of this review is to highlight recent discoveries regarding the intracellular signaling mechanisms that appear to play a critical role in persistent inflammatory and neuropathic pain. The review will focus on the mitogen activated protein kinase family of enzymes and the data suggesting that treatments designed to inhibit the activation of these enzymes may lead to significant advancements in the treatment of chronic pain. The review will also highlight the important interplay between neurons and non-neuronal cells (i.e., microglia and astrocytes) within the dorsal horn of the spinal cord in the generation and maintenance of chronic inflammatory and neuropathic pain." @default.
- W2000696560 created "2016-06-24" @default.
- W2000696560 creator A5089557712 @default.
- W2000696560 date "2012-04-01" @default.
- W2000696560 modified "2023-10-02" @default.
- W2000696560 title "The role of mitogen activated protein kinase signaling in microglia and neurons in the initiation and maintenance of chronic pain" @default.
- W2000696560 cites W1841237986 @default.
- W2000696560 cites W1879507096 @default.
- W2000696560 cites W1896731805 @default.
- W2000696560 cites W1941739558 @default.
- W2000696560 cites W1963931057 @default.
- W2000696560 cites W1965866432 @default.
- W2000696560 cites W1967603825 @default.
- W2000696560 cites W1969561355 @default.
- W2000696560 cites W1969889453 @default.
- W2000696560 cites W1971592437 @default.
- W2000696560 cites W1972659294 @default.
- W2000696560 cites W1972956052 @default.
- W2000696560 cites W1973586899 @default.
- W2000696560 cites W1975724680 @default.
- W2000696560 cites W1979288311 @default.
- W2000696560 cites W1979859079 @default.
- W2000696560 cites W1980241739 @default.
- W2000696560 cites W1980365490 @default.
- W2000696560 cites W1981309231 @default.
- W2000696560 cites W1983973921 @default.
- W2000696560 cites W1986237413 @default.
- W2000696560 cites W1989274659 @default.
- W2000696560 cites W1995275029 @default.
- W2000696560 cites W1996770323 @default.
- W2000696560 cites W1998071315 @default.
- W2000696560 cites W2003646312 @default.
- W2000696560 cites W2006161356 @default.
- W2000696560 cites W2006589555 @default.
- W2000696560 cites W2010376916 @default.
- W2000696560 cites W2015264121 @default.
- W2000696560 cites W2016542037 @default.
- W2000696560 cites W2016936987 @default.
- W2000696560 cites W2017357594 @default.
- W2000696560 cites W2017441297 @default.
- W2000696560 cites W2019213708 @default.
- W2000696560 cites W2020518352 @default.
- W2000696560 cites W2021904427 @default.
- W2000696560 cites W2024790778 @default.
- W2000696560 cites W2026393874 @default.
- W2000696560 cites W2029968439 @default.
- W2000696560 cites W2030205108 @default.
- W2000696560 cites W2030337358 @default.
- W2000696560 cites W2036878027 @default.
- W2000696560 cites W2038089520 @default.
- W2000696560 cites W2039871355 @default.
- W2000696560 cites W2047010161 @default.
- W2000696560 cites W2047794539 @default.
- W2000696560 cites W2058020736 @default.
- W2000696560 cites W2059646315 @default.
- W2000696560 cites W2060572373 @default.
- W2000696560 cites W2061134322 @default.
- W2000696560 cites W2063153146 @default.
- W2000696560 cites W2064765332 @default.
- W2000696560 cites W2067899795 @default.
- W2000696560 cites W2067924690 @default.
- W2000696560 cites W2069886558 @default.
- W2000696560 cites W2071450269 @default.
- W2000696560 cites W2074098537 @default.
- W2000696560 cites W2077358692 @default.
- W2000696560 cites W2079692119 @default.
- W2000696560 cites W2081130105 @default.
- W2000696560 cites W2084192369 @default.
- W2000696560 cites W2084335181 @default.
- W2000696560 cites W2085666180 @default.
- W2000696560 cites W2085864993 @default.
- W2000696560 cites W2086187702 @default.
- W2000696560 cites W2088311820 @default.
- W2000696560 cites W2094115539 @default.
- W2000696560 cites W2098719212 @default.
- W2000696560 cites W2100717906 @default.
- W2000696560 cites W2105651504 @default.
- W2000696560 cites W2115369213 @default.
- W2000696560 cites W2115601182 @default.
- W2000696560 cites W2122516991 @default.
- W2000696560 cites W2122778405 @default.
- W2000696560 cites W2129531706 @default.
- W2000696560 cites W2132420892 @default.
- W2000696560 cites W2133316133 @default.
- W2000696560 cites W2154806033 @default.
- W2000696560 cites W2159059571 @default.
- W2000696560 cites W2161534821 @default.
- W2000696560 cites W2163083170 @default.
- W2000696560 cites W2171883378 @default.
- W2000696560 cites W2172129201 @default.
- W2000696560 cites W2342903910 @default.
- W2000696560 doi "https://doi.org/10.1016/j.expneurol.2011.10.019" @default.
- W2000696560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22062045" @default.
- W2000696560 hasPublicationYear "2012" @default.
- W2000696560 type Work @default.
- W2000696560 sameAs 2000696560 @default.
- W2000696560 citedByCount "35" @default.
- W2000696560 countsByYear W20006965602012 @default.