FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000698498> ?p ?o ?g. }

• W2000698498 endingPage "202" @default.
• W2000698498 startingPage "192" @default.
• W2000698498 abstract "We have examined the influence of extracellular pH and calcium concentration on the action of glucagon on isolated rat hepatocytes, perfused liver or plasma membrane preparations. Incubation of rat hepatocytes with 10 nM glucagon at pH 7.4 caused an immediate increase in cAMP concentrations (8-fold), and this rise was almost 50% lower at acidic extracellular pH (6.9). This effect of pH could not be explained by an alteration of the hormone binding to its receptor for glucagon concentrations higher than 1 nM. The effect of acidosis on cAMP production was still present with non-hormonal effectors, such as 10 μM Gpp[NH]p, 30 μM forskolin or 10 mM NaF. This suggests a direct action of acidosis on the regulatory component Ns and/or on the catalytic subunit of adenylate cyclase. Acidic pH also depressed mitochondrial processes responsive to glucagon (NAD(P)H fluorescence, glutamine breakdown). Whatever the experimental model, calcium appeared to be required for maximal stimulation of cAMP production by glucagon. On perfused rat liver, glycogenolysis was depressed in the absence of extracellular calcium in the perfusate. In isolated hepatocytes, the stimulation of phosphorylase a activity by glucagon was modulated by extracellular calcium concentrations lower than 0.2 mM. This suggests that, although glucagon action is chiefly cAMP-mediated, its effect on calcium mobilization (affecting various cellular process, including cAMP production itself) should also be taken into account. This work also confirmed the importance of calcium in the stimulation of mitochondrial metabolism of glutamine by glucagon." @default.
• W2000698498 created "2016-06-24" @default.
• W2000698498 creator A5037206782 @default.
• W2000698498 creator A5059336112 @default.
• W2000698498 creator A5081409044 @default.
• W2000698498 date "1988-02-01" @default.
• W2000698498 modified "2023-10-12" @default.
• W2000698498 title "Modulation of glucagon effects by changes in extracellular pH and calcium" @default.
• W2000698498 cites W1487088904 @default.
• W2000698498 cites W1535670154 @default.
• W2000698498 cites W1561507845 @default.
• W2000698498 cites W1576014737 @default.
• W2000698498 cites W1581764898 @default.
• W2000698498 cites W1583720349 @default.
• W2000698498 cites W1586112062 @default.
• W2000698498 cites W1604711400 @default.
• W2000698498 cites W1605292446 @default.
• W2000698498 cites W1636707023 @default.
• W2000698498 cites W1676883243 @default.
• W2000698498 cites W1820905947 @default.
• W2000698498 cites W1967395137 @default.
• W2000698498 cites W1993722029 @default.
• W2000698498 cites W1994705025 @default.
• W2000698498 cites W2033930625 @default.
• W2000698498 cites W2054255911 @default.
• W2000698498 cites W2072482644 @default.
• W2000698498 cites W2084659235 @default.
• W2000698498 cites W2089751425 @default.
• W2000698498 cites W2090784961 @default.
• W2000698498 cites W2113943014 @default.
• W2000698498 cites W2116200052 @default.
• W2000698498 cites W2137242115 @default.
• W2000698498 cites W2162562517 @default.
• W2000698498 cites W2169174204 @default.
• W2000698498 cites W2190099331 @default.
• W2000698498 cites W2203986272 @default.
• W2000698498 cites W2224973710 @default.
• W2000698498 cites W2233127634 @default.
• W2000698498 cites W2242953838 @default.
• W2000698498 cites W2344493794 @default.
• W2000698498 cites W2415385291 @default.
• W2000698498 cites W245635694 @default.
• W2000698498 cites W67049710 @default.
• W2000698498 cites W82267760 @default.
• W2000698498 doi "https://doi.org/10.1016/0167-4889(88)90008-0" @default.
• W2000698498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2829979" @default.
• W2000698498 hasPublicationYear "1988" @default.
• W2000698498 type Work @default.
• W2000698498 sameAs 2000698498 @default.
• W2000698498 citedByCount "4" @default.
• W2000698498 crossrefType "journal-article" @default.
• W2000698498 hasAuthorship W2000698498A5037206782 @default.
• W2000698498 hasAuthorship W2000698498A5059336112 @default.
• W2000698498 hasAuthorship W2000698498A5081409044 @default.
• W2000698498 hasConcept C126322002 @default.
• W2000698498 hasConcept C134018914 @default.
• W2000698498 hasConcept C170493617 @default.
• W2000698498 hasConcept C180526460 @default.
• W2000698498 hasConcept C185592680 @default.
• W2000698498 hasConcept C204779464 @default.
• W2000698498 hasConcept C24998067 @default.
• W2000698498 hasConcept C2777499176 @default.
• W2000698498 hasConcept C2777949327 @default.
• W2000698498 hasConcept C2778563252 @default.
• W2000698498 hasConcept C2779276759 @default.
• W2000698498 hasConcept C28406088 @default.
• W2000698498 hasConcept C519063684 @default.
• W2000698498 hasConcept C55493867 @default.
• W2000698498 hasConcept C62231903 @default.
• W2000698498 hasConcept C71315377 @default.
• W2000698498 hasConcept C71924100 @default.
• W2000698498 hasConcept C86803240 @default.
• W2000698498 hasConceptScore W2000698498C126322002 @default.
• W2000698498 hasConceptScore W2000698498C134018914 @default.
• W2000698498 hasConceptScore W2000698498C170493617 @default.
• W2000698498 hasConceptScore W2000698498C180526460 @default.
• W2000698498 hasConceptScore W2000698498C185592680 @default.
• W2000698498 hasConceptScore W2000698498C204779464 @default.
• W2000698498 hasConceptScore W2000698498C24998067 @default.
• W2000698498 hasConceptScore W2000698498C2777499176 @default.
• W2000698498 hasConceptScore W2000698498C2777949327 @default.
• W2000698498 hasConceptScore W2000698498C2778563252 @default.
• W2000698498 hasConceptScore W2000698498C2779276759 @default.
• W2000698498 hasConceptScore W2000698498C28406088 @default.
• W2000698498 hasConceptScore W2000698498C519063684 @default.
• W2000698498 hasConceptScore W2000698498C55493867 @default.
• W2000698498 hasConceptScore W2000698498C62231903 @default.
• W2000698498 hasConceptScore W2000698498C71315377 @default.
• W2000698498 hasConceptScore W2000698498C71924100 @default.
• W2000698498 hasConceptScore W2000698498C86803240 @default.
• W2000698498 hasIssue "2" @default.
• W2000698498 hasLocation W20006984981 @default.
• W2000698498 hasLocation W20006984982 @default.
• W2000698498 hasOpenAccess W2000698498 @default.
• W2000698498 hasPrimaryLocation W20006984981 @default.
• W2000698498 hasRelatedWork W1998832524 @default.
• W2000698498 hasRelatedWork W2000698498 @default.
• W2000698498 hasRelatedWork W2026433816 @default.

• next