FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000698869> ?p ?o ?g. }

• W2000698869 endingPage "522" @default.
• W2000698869 startingPage "506" @default.
• W2000698869 abstract "Although circumcision reduces male acquisition of human immunodeficiency virus type-1 (HIV-1) by 60%, the initial mechanisms of HIV-1 transmission at the foreskin remain elusive. We have established two novel and complementary models of the human adult foreskin epithelium, namely, ex vivo foreskin explants and in vitro reconstructed immunocompetent foreskins. In these models, efficient HIV-1 transmission occurs after 1 h of polarized exposure of the inner, but not outer, foreskin to mononuclear cells highly infected with HIV-1, but not to cell-free virus. HIV-1-infected cells form viral synapses with apical foreskin keratinocytes, leading to polarized budding of HIV-1, which is rapidly internalized by Langerhans cells (LCs) in the inner foreskin. In turn, LCs migrate toward the epidermis–dermis interface to form conjugates with T cells, thereby transferring HIV-1. Seminal plasma mixed with cervicovaginal secretions inhibits HIV-1 translocation. This set of results rationalizes at the cellular level the apparent protective outcome of circumcision against HIV-1 acquisition by men." @default.
• W2000698869 created "2016-06-24" @default.
• W2000698869 creator A5010855767 @default.
• W2000698869 creator A5027231771 @default.
• W2000698869 creator A5030948367 @default.
• W2000698869 creator A5039276024 @default.
• W2000698869 creator A5050828277 @default.
• W2000698869 creator A5053947269 @default.
• W2000698869 creator A5057440453 @default.
• W2000698869 creator A5059129999 @default.
• W2000698869 creator A5069777709 @default.
• W2000698869 creator A5073196762 @default.
• W2000698869 date "2010-09-01" @default.
• W2000698869 modified "2023-10-01" @default.
• W2000698869 title "Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans–T cell conjugates" @default.
• W2000698869 cites W1498022547 @default.
• W2000698869 cites W1653335370 @default.
• W2000698869 cites W1653610605 @default.
• W2000698869 cites W1953625602 @default.
• W2000698869 cites W1963218108 @default.
• W2000698869 cites W1964716918 @default.
• W2000698869 cites W1966517369 @default.
• W2000698869 cites W1967348217 @default.
• W2000698869 cites W1974616965 @default.
• W2000698869 cites W1982126777 @default.
• W2000698869 cites W1982160212 @default.
• W2000698869 cites W1989025673 @default.
• W2000698869 cites W1990896467 @default.
• W2000698869 cites W2005764131 @default.
• W2000698869 cites W2007819953 @default.
• W2000698869 cites W2013948998 @default.
• W2000698869 cites W2022280258 @default.
• W2000698869 cites W2023923364 @default.
• W2000698869 cites W2028100045 @default.
• W2000698869 cites W2030541908 @default.
• W2000698869 cites W2040026254 @default.
• W2000698869 cites W2042207484 @default.
• W2000698869 cites W2052890141 @default.
• W2000698869 cites W2053601970 @default.
• W2000698869 cites W2062554490 @default.
• W2000698869 cites W2062561488 @default.
• W2000698869 cites W2071809465 @default.
• W2000698869 cites W2072126017 @default.
• W2000698869 cites W2073092958 @default.
• W2000698869 cites W2074620757 @default.
• W2000698869 cites W2074673603 @default.
• W2000698869 cites W2081497021 @default.
• W2000698869 cites W2083839657 @default.
• W2000698869 cites W2087166273 @default.
• W2000698869 cites W2088747167 @default.
• W2000698869 cites W2091514999 @default.
• W2000698869 cites W2092102002 @default.
• W2000698869 cites W2095272963 @default.
• W2000698869 cites W2107900780 @default.
• W2000698869 cites W2110673598 @default.
• W2000698869 cites W2114726166 @default.
• W2000698869 cites W2115373328 @default.
• W2000698869 cites W2119334940 @default.
• W2000698869 cites W2121750736 @default.
• W2000698869 cites W2123626917 @default.
• W2000698869 cites W2131878781 @default.
• W2000698869 cites W2139071750 @default.
• W2000698869 cites W2140065286 @default.
• W2000698869 cites W2141635380 @default.
• W2000698869 cites W2143071104 @default.
• W2000698869 cites W2145359348 @default.
• W2000698869 cites W2146428988 @default.
• W2000698869 cites W2149317992 @default.
• W2000698869 cites W2150959582 @default.
• W2000698869 cites W2155881222 @default.
• W2000698869 cites W2156489752 @default.
• W2000698869 cites W2165102472 @default.
• W2000698869 cites W2168527507 @default.
• W2000698869 cites W2168990603 @default.
• W2000698869 cites W2169672731 @default.
• W2000698869 cites W2181051474 @default.
• W2000698869 doi "https://doi.org/10.1038/mi.2010.32" @default.
• W2000698869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20571487" @default.
• W2000698869 hasPublicationYear "2010" @default.
• W2000698869 type Work @default.
• W2000698869 sameAs 2000698869 @default.
• W2000698869 citedByCount "137" @default.
• W2000698869 countsByYear W20006988692012 @default.
• W2000698869 countsByYear W20006988692013 @default.
• W2000698869 countsByYear W20006988692014 @default.
• W2000698869 countsByYear W20006988692015 @default.
• W2000698869 countsByYear W20006988692016 @default.
• W2000698869 countsByYear W20006988692017 @default.
• W2000698869 countsByYear W20006988692018 @default.
• W2000698869 countsByYear W20006988692019 @default.
• W2000698869 countsByYear W20006988692020 @default.
• W2000698869 countsByYear W20006988692021 @default.
• W2000698869 countsByYear W20006988692022 @default.
• W2000698869 countsByYear W20006988692023 @default.
• W2000698869 crossrefType "journal-article" @default.
• W2000698869 hasAuthorship W2000698869A5010855767 @default.
• W2000698869 hasAuthorship W2000698869A5027231771 @default.
• W2000698869 hasAuthorship W2000698869A5030948367 @default.

• next