FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000698961> ?p ?o ?g. }

• W2000698961 endingPage "125" @default.
• W2000698961 startingPage "103" @default.
• W2000698961 abstract "Fibronectins (FNs) are extracellular matrix glycoproteins that are essential for embryonic development. In order to gain clues to possible developmental roles played by the particular isoforms of FN, we used indirect immunofluorescence microscopy to examine and compare the distributions of the alternatively spliced EIIIB, EIIIA, and V segments, as well as the total pool of FNs, in serial sections from mouse embryos. Antibodies to each of these segments produced staining patterns that colocalized during gastrulation (E7.5) and during early morphogenesis of somites and notochord (E9.5). During the period of continuing organogenesis in the latter half of gestation (E10.5 to E16.5), the antibodies generally continued to produce similar staining patterns localized to epithelial basement membranes, stromal connective tissues, blood vessel walls, and muscles. However, as development proceeded, there was a gradual decline in the intensity of staining for the spliced segments relative to the total pool of FN, with a particularly noticeable decline in staining for EIIIB and EIIIA segments in certain glandular organs, including the liver. A specific reduction in expression of these latter two segments was also evident in the uterus and placenta at early timepoints in gestation. However, the most dramatic difference in the expression of the spliced segments occurred in developing hyaline cartilage, which showed a selective reduction in staining for the EIIIA segment that was evident in the axial skeletal precursors by E12.5 and complete throughout the embryo by E15.5. Our findings suggest that the alternatively spliced EIIIB, EIIIA, and V segments are included in the FN that is required for the morphogenesis of “FN dependent” structures, including somites, notochord, and the vasculature. Conversely, these segments would appear to play divergent, and sometimes exclusive, biological roles in specific tissues such as liver, cartilage, and placenta." @default.
• W2000698961 created "2016-06-24" @default.
• W2000698961 creator A5026174611 @default.
• W2000698961 creator A5030647867 @default.
• W2000698961 date "1996-01-01" @default.
• W2000698961 modified "2023-09-25" @default.
• W2000698961 title "Fibronectin Isoform Distribution in the Mouse I. The Alternatively Spliced EIIIB, EIIIA, and V Segments Show Widespread Codistribution in the Developing Mouse Embryo" @default.
• W2000698961 cites W1513220709 @default.
• W2000698961 cites W1557819931 @default.
• W2000698961 cites W1558749218 @default.
• W2000698961 cites W1568637272 @default.
• W2000698961 cites W1905978178 @default.
• W2000698961 cites W1962262283 @default.
• W2000698961 cites W1963631969 @default.
• W2000698961 cites W1979822059 @default.
• W2000698961 cites W1989791832 @default.
• W2000698961 cites W1992394464 @default.
• W2000698961 cites W1999916897 @default.
• W2000698961 cites W2006576749 @default.
• W2000698961 cites W2013403635 @default.
• W2000698961 cites W2024373128 @default.
• W2000698961 cites W2025889573 @default.
• W2000698961 cites W2042233303 @default.
• W2000698961 cites W2044144438 @default.
• W2000698961 cites W2052332932 @default.
• W2000698961 cites W2053984681 @default.
• W2000698961 cites W2055560656 @default.
• W2000698961 cites W2056042928 @default.
• W2000698961 cites W2062582674 @default.
• W2000698961 cites W2063338234 @default.
• W2000698961 cites W2065749063 @default.
• W2000698961 cites W2066188919 @default.
• W2000698961 cites W2069027419 @default.
• W2000698961 cites W2073771842 @default.
• W2000698961 cites W2074114445 @default.
• W2000698961 cites W2074660013 @default.
• W2000698961 cites W2080568372 @default.
• W2000698961 cites W2096081784 @default.
• W2000698961 cites W2102915331 @default.
• W2000698961 cites W2107839231 @default.
• W2000698961 cites W2123832217 @default.
• W2000698961 cites W2142395014 @default.
• W2000698961 cites W2165539456 @default.
• W2000698961 cites W2166269000 @default.
• W2000698961 cites W2181382912 @default.
• W2000698961 cites W2188422153 @default.
• W2000698961 cites W2398689627 @default.
• W2000698961 doi "https://doi.org/10.3109/15419069609010766" @default.
• W2000698961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8937746" @default.
• W2000698961 hasPublicationYear "1996" @default.
• W2000698961 type Work @default.
• W2000698961 sameAs 2000698961 @default.
• W2000698961 citedByCount "81" @default.
• W2000698961 countsByYear W20006989612012 @default.
• W2000698961 countsByYear W20006989612013 @default.
• W2000698961 countsByYear W20006989612015 @default.
• W2000698961 countsByYear W20006989612016 @default.
• W2000698961 countsByYear W20006989612017 @default.
• W2000698961 countsByYear W20006989612018 @default.
• W2000698961 countsByYear W20006989612019 @default.
• W2000698961 countsByYear W20006989612020 @default.
• W2000698961 countsByYear W20006989612021 @default.
• W2000698961 countsByYear W20006989612022 @default.
• W2000698961 countsByYear W20006989612023 @default.
• W2000698961 crossrefType "journal-article" @default.
• W2000698961 hasAuthorship W2000698961A5026174611 @default.
• W2000698961 hasAuthorship W2000698961A5030647867 @default.
• W2000698961 hasConcept C104317684 @default.
• W2000698961 hasConcept C129536746 @default.
• W2000698961 hasConcept C153911025 @default.
• W2000698961 hasConcept C189165786 @default.
• W2000698961 hasConcept C196843134 @default.
• W2000698961 hasConcept C2776133846 @default.
• W2000698961 hasConcept C40692019 @default.
• W2000698961 hasConcept C53345823 @default.
• W2000698961 hasConcept C54355233 @default.
• W2000698961 hasConcept C74864618 @default.
• W2000698961 hasConcept C86492073 @default.
• W2000698961 hasConcept C86803240 @default.
• W2000698961 hasConcept C87073359 @default.
• W2000698961 hasConcept C95444343 @default.
• W2000698961 hasConceptScore W2000698961C104317684 @default.
• W2000698961 hasConceptScore W2000698961C129536746 @default.
• W2000698961 hasConceptScore W2000698961C153911025 @default.
• W2000698961 hasConceptScore W2000698961C189165786 @default.
• W2000698961 hasConceptScore W2000698961C196843134 @default.
• W2000698961 hasConceptScore W2000698961C2776133846 @default.
• W2000698961 hasConceptScore W2000698961C40692019 @default.
• W2000698961 hasConceptScore W2000698961C53345823 @default.
• W2000698961 hasConceptScore W2000698961C54355233 @default.
• W2000698961 hasConceptScore W2000698961C74864618 @default.
• W2000698961 hasConceptScore W2000698961C86492073 @default.
• W2000698961 hasConceptScore W2000698961C86803240 @default.
• W2000698961 hasConceptScore W2000698961C87073359 @default.
• W2000698961 hasConceptScore W2000698961C95444343 @default.
• W2000698961 hasIssue "2" @default.
• W2000698961 hasLocation W20006989611 @default.
• W2000698961 hasLocation W20006989612 @default.

• next