FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000699355> ?p ?o ?g. }

• W2000699355 endingPage "51" @default.
• W2000699355 startingPage "41" @default.
• W2000699355 abstract "Common marmosets (Callithrix jacchus) have become a useful animal model, particularly for development of biopharmaceuticals. While various renal failure models have been established in rodents, there is currently no acceptable model in marmosets. We analyzed the damaged renal tubules and tubulointerstitial changes (inflammation and fibrosis) of 5/6 nephrectomized (Nx) common marmosets by histopathological/immunohistochemical methods, and compared these findings to those in 5/6 Nx SD rats. In Nx marmosets and rats sacrificed at 5 and 13 weeks after Nx, variously dilated and atrophied renal tubules were seen in the cortex in common; however, the epithelial proliferating activity was much less in Nx marmosets. Furthermore, the degrees of inflammation and fibrosis seen in the affected cortex were more severe and massive in Nx marmosets with time-dependent increase. Interestingly, inflammation in Nx marmosets, of which degree was less in Nx rats, consisted of a large number of CD3-positive T cells and CD20-positive B cells (occasionally forming follicles), and a few CD68-positive macrophages. Based on these findings, lymphocytes might contribute to the progressive renal lesions in Nx marmosets. Fibrotic areas in Nx marmosets comprised myofibroblasts expressing vimentin and α-smooth muscle actin (α-SMA), whereas along with vimentin and α-SMA expressions, desmin was expressed in myofibroblasts in Nx rats. This study shows that there are some differences in renal lesions induced by Nx between marmosets and rats, which would provide useful, base-line information for pharmacology and toxicology studies using Nx marmosets." @default.
• W2000699355 created "2016-06-24" @default.
• W2000699355 creator A5005006456 @default.
• W2000699355 creator A5008044947 @default.
• W2000699355 creator A5009514473 @default.
• W2000699355 creator A5013893275 @default.
• W2000699355 creator A5022815485 @default.
• W2000699355 creator A5026497309 @default.
• W2000699355 creator A5073217486 @default.
• W2000699355 creator A5074976183 @default.
• W2000699355 creator A5089170879 @default.
• W2000699355 date "2015-01-01" @default.
• W2000699355 modified "2023-09-27" @default.
• W2000699355 title "Histopathological characterization of renal tubular and interstitial changes in 5/6 nephrectomized marmoset monkeys (Callithrix jacchus)" @default.
• W2000699355 cites W1552991827 @default.
• W2000699355 cites W1557028690 @default.
• W2000699355 cites W1964177773 @default.
• W2000699355 cites W1966291644 @default.
• W2000699355 cites W1975569148 @default.
• W2000699355 cites W1982049148 @default.
• W2000699355 cites W1993985512 @default.
• W2000699355 cites W2007575441 @default.
• W2000699355 cites W2010449491 @default.
• W2000699355 cites W2017200377 @default.
• W2000699355 cites W2017851358 @default.
• W2000699355 cites W2020981536 @default.
• W2000699355 cites W2026529532 @default.
• W2000699355 cites W2027244863 @default.
• W2000699355 cites W2047225646 @default.
• W2000699355 cites W2049384286 @default.
• W2000699355 cites W2051267756 @default.
• W2000699355 cites W2052679130 @default.
• W2000699355 cites W2053564725 @default.
• W2000699355 cites W2055142209 @default.
• W2000699355 cites W2056057174 @default.
• W2000699355 cites W2067408124 @default.
• W2000699355 cites W2070237364 @default.
• W2000699355 cites W2083358902 @default.
• W2000699355 cites W2086331541 @default.
• W2000699355 cites W2095253772 @default.
• W2000699355 cites W2096850473 @default.
• W2000699355 cites W2102822503 @default.
• W2000699355 cites W2113456660 @default.
• W2000699355 cites W2127530565 @default.
• W2000699355 cites W2147161251 @default.
• W2000699355 cites W2148184356 @default.
• W2000699355 cites W2170783508 @default.
• W2000699355 cites W2171911714 @default.
• W2000699355 cites W2267373467 @default.
• W2000699355 doi "https://doi.org/10.1016/j.etp.2014.09.007" @default.
• W2000699355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446802" @default.
• W2000699355 hasPublicationYear "2015" @default.
• W2000699355 type Work @default.
• W2000699355 sameAs 2000699355 @default.
• W2000699355 citedByCount "3" @default.
• W2000699355 countsByYear W20006993552016 @default.
• W2000699355 countsByYear W20006993552017 @default.
• W2000699355 countsByYear W20006993552019 @default.
• W2000699355 crossrefType "journal-article" @default.
• W2000699355 hasAuthorship W2000699355A5005006456 @default.
• W2000699355 hasAuthorship W2000699355A5008044947 @default.
• W2000699355 hasAuthorship W2000699355A5009514473 @default.
• W2000699355 hasAuthorship W2000699355A5013893275 @default.
• W2000699355 hasAuthorship W2000699355A5022815485 @default.
• W2000699355 hasAuthorship W2000699355A5026497309 @default.
• W2000699355 hasAuthorship W2000699355A5073217486 @default.
• W2000699355 hasAuthorship W2000699355A5074976183 @default.
• W2000699355 hasAuthorship W2000699355A5089170879 @default.
• W2000699355 hasConcept C134018914 @default.
• W2000699355 hasConcept C142724271 @default.
• W2000699355 hasConcept C147447768 @default.
• W2000699355 hasConcept C151730666 @default.
• W2000699355 hasConcept C203014093 @default.
• W2000699355 hasConcept C204232928 @default.
• W2000699355 hasConcept C207865475 @default.
• W2000699355 hasConcept C2776453536 @default.
• W2000699355 hasConcept C2776460901 @default.
• W2000699355 hasConcept C2776914184 @default.
• W2000699355 hasConcept C2778577996 @default.
• W2000699355 hasConcept C2779072444 @default.
• W2000699355 hasConcept C2779504336 @default.
• W2000699355 hasConcept C2780091579 @default.
• W2000699355 hasConcept C2780559512 @default.
• W2000699355 hasConcept C71924100 @default.
• W2000699355 hasConcept C86803240 @default.
• W2000699355 hasConceptScore W2000699355C134018914 @default.
• W2000699355 hasConceptScore W2000699355C142724271 @default.
• W2000699355 hasConceptScore W2000699355C147447768 @default.
• W2000699355 hasConceptScore W2000699355C151730666 @default.
• W2000699355 hasConceptScore W2000699355C203014093 @default.
• W2000699355 hasConceptScore W2000699355C204232928 @default.
• W2000699355 hasConceptScore W2000699355C207865475 @default.
• W2000699355 hasConceptScore W2000699355C2776453536 @default.
• W2000699355 hasConceptScore W2000699355C2776460901 @default.
• W2000699355 hasConceptScore W2000699355C2776914184 @default.
• W2000699355 hasConceptScore W2000699355C2778577996 @default.
• W2000699355 hasConceptScore W2000699355C2779072444 @default.
• W2000699355 hasConceptScore W2000699355C2779504336 @default.

• next