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- W2000700084 abstract "We have reported the design of polyvalent synthetic and recombinant chimeras that include promiscuous T cell epitopes as a viable delivery system for pre-erythrocytic subunit malaria vaccines. To further assess the ability of several Plasmodium T cell epitopes to enhance vaccine potency, we designed a synthetic gene encoding four Plasmodium yoelii merozoite surface protein 1 (PyMSP1) CD4+ promiscuous T cell epitopes fused in tandem to the homologous carboxyl terminal PyMSP119 fragment. This Recombinant Modular Chimera (PyRMC-MSP119) was tested for immunogenicity and protective efficacy in comparative experiments with a recombinant protein expressing only the PyMSP119 fragment. Both proteins induced comparable antibody responses. However PyRMC-MSP119 elicited higher anti-parasite antibody titers and more robust protection against both hyper-parasitemia and malarial anemia. Most importantly, passive transfer of anti-PyRMC-MSP119, but not anti-PyMSP119 antibodies protected against heterologous challenge. These studies show that protective efficacy can be significantly improved by inclusion of an array of autologous promiscuous T cell epitopes in vaccine constructs." @default.
- W2000700084 created "2016-06-24" @default.
- W2000700084 creator A5041269746 @default.
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- W2000700084 creator A5074016992 @default.
- W2000700084 date "2010-03-01" @default.
- W2000700084 modified "2023-09-30" @default.
- W2000700084 title "Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate" @default.
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- W2000700084 doi "https://doi.org/10.1016/j.vaccine.2010.01.019" @default.
- W2000700084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844075" @default.
- W2000700084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20097151" @default.
- W2000700084 hasPublicationYear "2010" @default.
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