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- W2000700855 abstract "To determine the absorption and the release of mitomycin-C from a collagen implant and tissue impregnation in the anterior structures of the rabbit eye.Determining the quantity of mitomycin-C that a collagen implant can absorb with the difference between dry and soaked weight. Mitomycin-C release was measured in vitro using spectrophotometry. The measurement was repeated using a bioassay. Ocular tissue impregnation was determined in 12 eyes of six rabbits. Sclera, implant, aqueous, and ciliary body specimens were collected for concentration measurement using HPLC from 1 to 6 h after surgery.The mean mitomycin-C quantity absorbed in the implant was 3.22+/-0.2 microg. In vitro release was 0.13 mg/ml after 10 min and 0.05 microg/ml at 6 h. The bioassay showed almost no antifibrotic activity in sclera. In vivo release of mitomycin-C was high from the first to the sixth hour.After filtering surgery, mitomycin-C in the collagen implant is clearly released and ocular tissues are effectively impregnated." @default.
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- W2000700855 date "2006-11-01" @default.
- W2000700855 modified "2023-10-15" @default.
- W2000700855 title "Dosage et cinétique de libération de mitomycine C d’un implant de collagène utilisé comme moyen d’administration lors d’une chirurgie filtrante chez le lapin" @default.
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- W2000700855 doi "https://doi.org/10.1016/s0181-5512(06)73893-1" @default.
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