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• W2000703221 abstract "Purpose of review The prevalence of obesity in youth is increasing alarmingly among children and adolescents in the United States. The problem falls disproportionately on African-American and Hispanic children. Many of the metabolic and cardiovascular complications associated with obesity are already present during childhood and are closely linked to the concomitant insulin resistance/hyperinsulinemia and degree of obesity. Moreover, these co-morbidities persist into adulthood. Recent findings The progression from normal glucose tolerance to type 2 diabetes mellitus involves an intermediate stage known as prediabetes or impaired glucose regulation. Prediabetes is characterized by peripheral insulin-resistance and impaired glucose sensitivity of first-phase insulin secretion. On the other hand, in overt type 2 diabetes mellitus β-cell failure becomes fully manifested. Progression from prediabetes to type 2 diabetes mellitus in youth is characterized by marked weight gain and further reduction in insulin secretion and insulin resistance. Summary Reverting obesity through lifestyle modification, that involves nutrition education, behavior modification and exercise, is an important step to prevent the progression to diabetes." @default.
• W2000703221 created "2016-06-24" @default.
• W2000703221 creator A5007575456 @default.
• W2000703221 creator A5023870801 @default.
• W2000703221 date "2008-04-01" @default.
• W2000703221 modified "2023-09-27" @default.
• W2000703221 title "Prediabetes and type 2 diabetes in youth: an emerging epidemic disease?" @default.
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• W2000703221 doi "https://doi.org/10.1097/med.0b013e3282f57251" @default.
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