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• W2000704250 endingPage "8721" @default.
• W2000704250 startingPage "8710" @default.
• W2000704250 abstract "Previously, we reported that human papillomavirus (HPV) type 16 E6 binds to C/H1, C/H3, and the C-terminal domains of coactivators p300 and CBP, causing the modulation of the transcription of certain genes controlled by NF-kappaB (p65 or relA) and p53. To establish the biological significance of these observations, we have focused on the transcriptional regulation of interleukin-8 (IL-8), a potent chemoattractant for T lymphocytes and neutrophils, which is also essential for the initiation of the local immune response. The IL-8 promoter is regulated by NF-kappaB/p65 in response to tumor necrosis factor alpha and requires the cooperation of the coactivators CBP/p300 and steroid receptor coactivator 1 (SRC-1) and the p300/CBP-associated factor (P/CAF) for optimal activation. Here we report that, in the presence of HPV-16 E6, the promoter activity of IL-8 was repressed. Moreover, from the mutational analysis of the IL-8 promoter, we found that E6 down-regulates the IL-8 promoter activity through the NF-kappaB/p65 binding site. This inhibition appears to result from the ability of HPV-16 E6 to compete with NF-kappaB/p65 and SRC-1 for binding to the N terminus and C terminus of CBP, respectively. Reporter data also showed that E7 represses IL-8 promoter activity, though to a lesser extent than E6 but, like E6, the repression by E7 is through the NF-kappaB/p65 binding site. E7 was shown for the first time to bind to P/CAF, and the binding was necessary for the down regulation of the IL-8 promoter. E6 and E7 together inhibited transcription of the IL-8 promoter to a greater extent than either alone. Finally, by RNase protection assay, we showed that the synthesis of endogenous IL-8 mRNA was repressed in keratinocytes stably expressing E6 and E7. Taken together, the results provide evidence that E6 and E7 can cooperatively disrupt IL-8 transcription through disruption of transcriptional active complexes, and this may have important consequences for immune responses in infected hosts." @default.
• W2000704250 created "2016-06-24" @default.
• W2000704250 creator A5046878084 @default.
• W2000704250 creator A5048289298 @default.
• W2000704250 date "2002-09-01" @default.
• W2000704250 modified "2023-09-24" @default.
• W2000704250 title "Down Regulation of the Interleukin-8 Promoter by Human Papillomavirus Type 16 E6 and E7 through Effects on CREB Binding Protein/p300 and P/CAF" @default.
• W2000704250 cites W131975224 @default.
• W2000704250 cites W1486150850 @default.
• W2000704250 cites W1501286679 @default.
• W2000704250 cites W1501690710 @default.
• W2000704250 cites W1503003173 @default.
• W2000704250 cites W1511823445 @default.
• W2000704250 cites W1512653355 @default.
• W2000704250 cites W1529655352 @default.
• W2000704250 cites W1532255632 @default.
• W2000704250 cites W1587291838 @default.
• W2000704250 cites W1602446144 @default.
• W2000704250 cites W1613446635 @default.
• W2000704250 cites W1636221253 @default.
• W2000704250 cites W1643056575 @default.
• W2000704250 cites W1644306425 @default.
• W2000704250 cites W1676185943 @default.
• W2000704250 cites W1785443726 @default.
• W2000704250 cites W1807948597 @default.
• W2000704250 cites W1825540737 @default.
• W2000704250 cites W190015672 @default.
• W2000704250 cites W1964337986 @default.
• W2000704250 cites W1966063731 @default.
• W2000704250 cites W1966804156 @default.
• W2000704250 cites W1968801618 @default.
• W2000704250 cites W1976140288 @default.
• W2000704250 cites W1978943108 @default.
• W2000704250 cites W1983239749 @default.
• W2000704250 cites W1985118687 @default.
• W2000704250 cites W1991185690 @default.
• W2000704250 cites W2003135979 @default.
• W2000704250 cites W2003393099 @default.
• W2000704250 cites W2006305989 @default.
• W2000704250 cites W2006659499 @default.
• W2000704250 cites W2011781801 @default.
• W2000704250 cites W2021787959 @default.
• W2000704250 cites W2033529039 @default.
• W2000704250 cites W2037626623 @default.
• W2000704250 cites W2038500217 @default.
• W2000704250 cites W2045279400 @default.
• W2000704250 cites W2046764234 @default.
• W2000704250 cites W2049986428 @default.
• W2000704250 cites W2050311264 @default.
• W2000704250 cites W2051211734 @default.
• W2000704250 cites W2057110731 @default.
• W2000704250 cites W2064726837 @default.
• W2000704250 cites W2077300798 @default.
• W2000704250 cites W2078912202 @default.
• W2000704250 cites W2079003739 @default.
• W2000704250 cites W2085615781 @default.
• W2000704250 cites W2086008721 @default.
• W2000704250 cites W2088549259 @default.
• W2000704250 cites W2091766380 @default.
• W2000704250 cites W2092722802 @default.
• W2000704250 cites W2094558395 @default.
• W2000704250 cites W2094648771 @default.
• W2000704250 cites W2095217266 @default.
• W2000704250 cites W2099680656 @default.
• W2000704250 cites W2108720228 @default.
• W2000704250 cites W2112280022 @default.
• W2000704250 cites W2115034716 @default.
• W2000704250 cites W2122413073 @default.
• W2000704250 cites W2123898551 @default.
• W2000704250 cites W2127532387 @default.
• W2000704250 cites W2129923536 @default.
• W2000704250 cites W2138027990 @default.
• W2000704250 cites W2141686420 @default.
• W2000704250 cites W2142277736 @default.
• W2000704250 cites W2143241514 @default.
• W2000704250 cites W2148020952 @default.
• W2000704250 cites W2148487263 @default.
• W2000704250 cites W2151071075 @default.
• W2000704250 cites W2154147940 @default.
• W2000704250 cites W2159833023 @default.
• W2000704250 cites W2170939558 @default.
• W2000704250 cites W2176220887 @default.
• W2000704250 cites W2182162711 @default.
• W2000704250 cites W2327241883 @default.
• W2000704250 cites W2337028134 @default.
• W2000704250 cites W2347113937 @default.
• W2000704250 cites W2398969482 @default.
• W2000704250 cites W303337234 @default.
• W2000704250 cites W3216853214 @default.
• W2000704250 cites W4313333721 @default.
• W2000704250 cites W55000995 @default.
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• W2000704250 doi "https://doi.org/10.1128/jvi.76.17.8710-8721.2002" @default.
• W2000704250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136974" @default.
• W2000704250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12163591" @default.
• W2000704250 hasPublicationYear "2002" @default.
• W2000704250 type Work @default.
• W2000704250 sameAs 2000704250 @default.

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