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- W2000704637 abstract "Abstract The cellular pharmacology of the D- and L-enantiomers of β-5-o-carboranyl-2′-deoxyuridine (CDU), compounds designed for boron neutron capture therapy (BNCT), were studied using human CEM lymphoblast and U-251 glioblastoma cells, at a physiologically achievable concentration (1 μM). Accumulation of the enantiomers was rapid and indistinguishable, reaching cellular concentrations > 40-fold higher than extracellular levels, with ∼5% persisting in cells after incubation in fresh medium for more than 2 hr. Uptake was not affected by nucleoside uptake inhibitors, but was inhibited by the purine base uptake inhibitor papaverine." @default.
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- W2000704637 date "2000-03-01" @default.
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- W2000704637 title "Cellular Pharmacology of the<scp>D</scp>- and<scp>L</scp>-Enantiomers of β-5-<i>o</i>-Carboranyl-2′-deoxyuridine" @default.
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- W2000704637 doi "https://doi.org/10.1080/15257770008035016" @default.
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