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- W2000704821 abstract "A series of 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes 2a-c and 4 and a related acyclic analogue 6a were synthesised and converted to the corresponding Mannich bases 3a-c, 5 and 6b. Evaluation of these compounds against murine P388 and L1210 cells as well as human Molt 4/C8 and CEM T-lymphocytes revealed that the Mannich bases were more cytotoxic than the corresponding unsaturated ketones. 1,4-bis(3-Dimethylaminomethyl-2-oxo-1-cyclohexylmethylene)benzene dihydrochloride (3a) had lower IC(50) values than melphalan against the four cell lines and was 15 times more potent than this drug when examined against a panel of human tumours." @default.
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- W2000704821 date "2002-01-01" @default.
- W2000704821 modified "2023-09-26" @default.
- W2000704821 title "Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds" @default.
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- W2000704821 doi "https://doi.org/10.1016/s0223-5234(01)01294-6" @default.
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