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- W2000705887 abstract "Prostate cancer, the most common nonskin cancer in men, is estimated to cause 27,000 deaths annually in the USA. With the advent of prostate-specific antigen screening, most are diagnosed with local disease, but approximately one-third of patients ultimately develop recurrence despite definitive local therapy. Despite the high initial response rate to androgen deprivation, castration resistance eventually develops. In this article, we examine mechanisms of androgen resistance and further discuss current progress in the development of novel endocrine therapy in the treatment of castration-resistant prostate cancer. We also explore the rationale of complete androgen blockade, with current ongoing investigation of combination hormonal therapy in this context." @default.
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- W2000705887 date "2011-04-01" @default.
- W2000705887 modified "2023-09-26" @default.
- W2000705887 title "Endocrine therapy for prostate cancer: review of the latest clinical evidence" @default.
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- W2000705887 doi "https://doi.org/10.4155/cli.11.28" @default.
- W2000705887 hasPublicationYear "2011" @default.
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