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- W2000706477 abstract "The effect of concentration and exposure time on the postantibiotic effect (PAE) of sparfloxacin and ciprofloxacin against Pseudomonas aeruginosa Psa-1 and Enterococcus faecalis SD-63 was evaluated by the colony counting method using centrifugation to remove the antibiotic. The microorganisms were exposed for 15, 30 and 60min to drug concentrations ranging from 1 × MIC to 31 × MIC. The PAE was calculated as the difference in time required by test and control cultures to increase 1 log10 after the drug was removed. The MICs of sparfloxacin for P. aeruginosa and E. faecalis were 0.50 mg/L and 0.25 mg/L, respectively, whereas the MICs of ciprofloxacin were 0.25 mg/L for P. aeruginosa and 0.50 mg/L for E. faecalis. PAEs increased as a function of concentration and exposure time. Against E. faecalis no point of maximal response was reached. On the contrary, against P. aeruginosa this point was reached at 8 × MIC of ciprofloxacin and 16 × MIC of sparfloxacin PAE values of sparfloxacin for P. aeruginosa and E. faecalis ranged from 7 to 96 min and from 0 to 112 min, respectively, and those of ciprofloxacin from 8.5 to 82.33 min and from 0 to > 136 min, respectively. Significant PAEs for P. aeruginosa were obtained after 60 min exposure at 4 × MIC (62.6 min) and 2 × MIC (52.6 min) of ciprofloxacin and sparfloxacin, respectively, and at 8 × MIC (81.5 min) and 16 × MIC (81.6 min) for E. faecalis. Both quinolones showed longer PAEs against P. aeruginosa than against E. faecalis, except at concentrations above 8 × MIC of ciprofloxacin and 16 × MIC of sparfloxacin where PAEs produced against E. faecalis were longer." @default.
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- W2000706477 date "1994-01-01" @default.
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- W2000706477 title "In-vitro postantibiotic effect of sparfloxacin and ciprofloxacin against Pseudomonas aeruginosa and Enterococcus faecalis" @default.
- W2000706477 doi "https://doi.org/10.1093/jac/34.5.679" @default.
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