Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000706626> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2000706626 endingPage "1314" @default.
- W2000706626 startingPage "1306" @default.
- W2000706626 abstract "In this study, we investigated the in vitro potential of the bioactive extracts from five putatively novel species of actinomycetes isolated from the Indian hot desert against multi‐drug resistant (MDR) Streptococcus pneumoniae. The antimicrobial activity of 10 different extracts was evaluated against S. pneumoniae strains with, erm(B) and mef(E) genes as well as fluoroquinolone‐resistant (FQR) strains using the micro‐broth dilution method. Of these 10 extracts, four exhibited good to excellent anti‐S. pneumoniae activity with minimum inhibitory concentrations (MICs) ranging from 0·125 to 8 μg ml−1. The time‐kill kinetics study showed that these extracts killed the pathogens in 2–8 h. In vitro cell‐free transcription/translation of luciferase gene using S30 bacterial extract and TNT mammalian ribosome indicated that they inhibited bacterial ribosomes at much lower concentrations than those required to inhibit the mammalian ribosomes. This study demonstrates that these are potent concentration‐dependent bactericidal metabolites with 16‐fold higher in vitro activity than levofloxacin against MDR S. pneumoniae. Metabolites from actinomycetes can be excellent inhibitors of MDR S. pneumoniae. Considering the in vitro efficacy of these crude extracts against S. pneumoniae MDR spp., once purified these can be used against streptococcal pathogens causing community‐acquired pneumonia." @default.
- W2000706626 created "2016-06-24" @default.
- W2000706626 creator A5003351348 @default.
- W2000706626 creator A5007488317 @default.
- W2000706626 creator A5028377131 @default.
- W2000706626 creator A5071756086 @default.
- W2000706626 date "2015-04-22" @default.
- W2000706626 modified "2023-09-27" @default.
- W2000706626 title "<i>In vitro</i>activity of bioactive extracts from rare actinomycetes against multi-drug resistant<i>Streptococcus pneumoniae</i>" @default.
- W2000706626 cites W1915177846 @default.
- W2000706626 cites W1973507391 @default.
- W2000706626 cites W1982017897 @default.
- W2000706626 cites W1985191032 @default.
- W2000706626 cites W1986439031 @default.
- W2000706626 cites W1987159881 @default.
- W2000706626 cites W2014649428 @default.
- W2000706626 cites W2032925644 @default.
- W2000706626 cites W2038507666 @default.
- W2000706626 cites W2065480048 @default.
- W2000706626 cites W2083827952 @default.
- W2000706626 cites W2091729115 @default.
- W2000706626 cites W2114167010 @default.
- W2000706626 cites W2116536963 @default.
- W2000706626 cites W2117892088 @default.
- W2000706626 cites W2121369371 @default.
- W2000706626 cites W2135688996 @default.
- W2000706626 cites W2138640953 @default.
- W2000706626 cites W2143391752 @default.
- W2000706626 cites W2145180649 @default.
- W2000706626 cites W2151455960 @default.
- W2000706626 cites W2163716559 @default.
- W2000706626 cites W2165829797 @default.
- W2000706626 cites W2273017175 @default.
- W2000706626 cites W2321085104 @default.
- W2000706626 doi "https://doi.org/10.1111/jam.12810" @default.
- W2000706626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25810118" @default.
- W2000706626 hasPublicationYear "2015" @default.
- W2000706626 type Work @default.
- W2000706626 sameAs 2000706626 @default.
- W2000706626 citedByCount "6" @default.
- W2000706626 countsByYear W20007066262016 @default.
- W2000706626 countsByYear W20007066262017 @default.
- W2000706626 countsByYear W20007066262018 @default.
- W2000706626 countsByYear W20007066262019 @default.
- W2000706626 countsByYear W20007066262023 @default.
- W2000706626 crossrefType "journal-article" @default.
- W2000706626 hasAuthorship W2000706626A5003351348 @default.
- W2000706626 hasAuthorship W2000706626A5007488317 @default.
- W2000706626 hasAuthorship W2000706626A5028377131 @default.
- W2000706626 hasAuthorship W2000706626A5071756086 @default.
- W2000706626 hasBestOaLocation W20007066261 @default.
- W2000706626 hasConcept C176947019 @default.
- W2000706626 hasConcept C202751555 @default.
- W2000706626 hasConcept C26381139 @default.
- W2000706626 hasConcept C2781253189 @default.
- W2000706626 hasConcept C2781276175 @default.
- W2000706626 hasConcept C4937899 @default.
- W2000706626 hasConcept C501593827 @default.
- W2000706626 hasConcept C55493867 @default.
- W2000706626 hasConcept C86803240 @default.
- W2000706626 hasConcept C89423630 @default.
- W2000706626 hasConceptScore W2000706626C176947019 @default.
- W2000706626 hasConceptScore W2000706626C202751555 @default.
- W2000706626 hasConceptScore W2000706626C26381139 @default.
- W2000706626 hasConceptScore W2000706626C2781253189 @default.
- W2000706626 hasConceptScore W2000706626C2781276175 @default.
- W2000706626 hasConceptScore W2000706626C4937899 @default.
- W2000706626 hasConceptScore W2000706626C501593827 @default.
- W2000706626 hasConceptScore W2000706626C55493867 @default.
- W2000706626 hasConceptScore W2000706626C86803240 @default.
- W2000706626 hasConceptScore W2000706626C89423630 @default.
- W2000706626 hasIssue "6" @default.
- W2000706626 hasLocation W20007066261 @default.
- W2000706626 hasLocation W20007066262 @default.
- W2000706626 hasOpenAccess W2000706626 @default.
- W2000706626 hasPrimaryLocation W20007066261 @default.
- W2000706626 hasRelatedWork W2050468734 @default.
- W2000706626 hasRelatedWork W2060556654 @default.
- W2000706626 hasRelatedWork W2064667003 @default.
- W2000706626 hasRelatedWork W2100856600 @default.
- W2000706626 hasRelatedWork W2163716559 @default.
- W2000706626 hasRelatedWork W2170382400 @default.
- W2000706626 hasRelatedWork W2331532123 @default.
- W2000706626 hasRelatedWork W2415840227 @default.
- W2000706626 hasRelatedWork W2980927461 @default.
- W2000706626 hasRelatedWork W4309271357 @default.
- W2000706626 hasVolume "118" @default.
- W2000706626 isParatext "false" @default.
- W2000706626 isRetracted "false" @default.
- W2000706626 magId "2000706626" @default.
- W2000706626 workType "article" @default.