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- W2000707118 abstract "Before the nerve contacts the skeletal muscle, the nicotinic acetylcholine receptors (nAChRs) form aggregates known as prepatterned clusters. We investigated their role in the occurrence of Ca(2+) spikes and twitching during myogenesis.Cultured mouse myotubes were used as cell models. Cells were subjected to a combination of immunostaining, Ca(2+) imaging and electrophysiological analysis.A single prepatterned nAChR cluster per myotube was generally detected. A correlation between formation of the prepatterned clusters and occurrence of Ca(2+) spikes and twitching was observed. Increase in size of the prepatterned clusters raised the frequency of Ca(2+) spikes and twitching. Blockade of the electrical activity triggered by the autocrine activation of prepatterned nAChR induced over-numbered nAChR clusters.Prepatterned nAChR aggregation is required for Ca(2+) spikes and twitching of developing myotubes. Moreover, prepatterned nAChR-driven electrical activity preserves the distribution of nAChRs, mimicking the effect of synaptic activity before innervation." @default.
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- W2000707118 date "2012-05-29" @default.
- W2000707118 modified "2023-10-09" @default.
- W2000707118 title "Novel role for prepatterned nicotinic acetylcholine receptors during myogenesis" @default.
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- W2000707118 doi "https://doi.org/10.1002/mus.23284" @default.
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